What can spontaneous fluctuations of the blood oxygenation-level-dependent signal tell us about psychiatric disorders?
What can spontaneous fluctuations of the blood oxygenation-level-dependent signal tell us about psychiatric disorders?
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DOI：
10.1097/yco.0b013e328337d78d
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发表时间：
2010-05-01
影响因子：
6.9
通讯作者：
Bullmore, Edward T.
中科院分区：
文献类型：
--
作者：
Fornito, Alex;Bullmore, Edward T.
综述目的静息态功能磁共振成像（rs-fMRI）是一种越来越流行的技术，用于研究精神病患者的脑功能障碍，并被广泛认为是测量功能性脑组织的内在属性。在这里，我们回顾的rs-fMRI研究的精神病人群，并考虑如何最近的证据有关的神经元的基础上，行为的相关性，和稳定的rs-fMRI措施可以通知和限制解释所获得的调查结果使用case-control designs.Recent findingsA范围的rs-fMRI措施已被应用到不同的患者群体，虽然调查结果并不总是一致的。rs-fMRI网络的大规模组织是强大的和可重复的，和rs-fMRI措施显示与精神病学相关的行为表型的相关性。然而，有证据表明，这些措施也受到先前的心理状态和背景，以及生理唤醒的个体差异的影响，可能有助于解释不一致的结果在病例对照comparison.Summaryrs-fMRI措施显示稳定和动态的属性，其性质才刚刚开始被发现。因此，解释患者和对照组之间的重大差异的rs-fMRI措施作为证据的改变，内在的功能性脑组织应谨慎进行。更好地了解自发脑动力学的稳定和短暂方面之间的关系将是必要的，以约束病例对照研究的解释和通知病理生理模型。
Purpose of reviewResting-state functional MRI (rs-fMRI) is an increasingly popular technique for studying brain dysfunction in psychiatric patients, and is widely assumed to measure intrinsic properties of functional brain organization. Here, we review rs-fMRI studies of psychiatric populations and consider how recent evidence concerning the neuronal basis, behavioural relevance, and the stability of rs-fMRI measures can inform and constrain interpretation of findings obtained using case-control designs.Recent findingsA range of rs-fMRI measures have been applied to different patient groups, although the findings have not always been consistent. The large-scale organization of rs-fMRI networks is robust and reproducible, and rs-fMRI measures show correlations with behavioural phenotypes relevant to psychiatry. However, evidence that such measures are also influenced by preceding psychological states and contexts, as well as individual variations in physiological arousal, may help to explain inconsistent findings in case-control comparisons.Summaryrs-fMRI measures show both stable and dynamic properties, the nature of which are only beginning to be uncovered. As such, interpreting significant differences between patients and controls on rs-fMRI measures as evidence for alterations in intrinsic functional brain organization should be done cautiously. Better understanding of the relationship between stable and transient aspects of spontaneous brain dynamics will be necessary to constrain interpretation of case-control studies and inform pathophysiological models.