The neurolathyrogen, β-N-oxalyl-L-α,β-diaminopropionic acid, is a potent agonist at ‘glutamate preferring’ receptors in the frog spinal cord
The neurolathyrogen, β-N-oxalyl-L-α,β-diaminopropionic acid, is a potent agonist at ‘glutamate preferring’ receptors in the frog spinal cord
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神经肽，β-N-草酰-L-α,β-二氨基丙酸，是青蛙脊髓中“谷氨酸偏好”受体的有效激动剂
DOI：
10.1016/0006-8993(81)90112-8
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
P. Nunn
中科院分区：
文献类型：
--
作者：
S. Pearson;P. Nunn
β-N-草酰-l-α，β-二氨基丙酸酯（β-ODP）是一种神经毒性氨基酸，可能是神经性山莨菪碱中毒的致病物质。β-ODAP和红藻氨酸盐似乎作用于共同的受体，因为它们的作用无法区分。这些结果可以解释一些神经性山慈菇中毒的症状。
A neurotoxic amino acid, β-N-oxalyl-l-α, β-diaminopropionate (β-ODP), found in seeds ofLathyrus sativusand a possible causative agent of neurolathyrism, was equipotent with kainate as a depolarizing agent on frog spinal cord ventral roots. β-ODAP and kainate appeared to act on a common receptor, as their actions could not be differentiated pharmacologically. These results could explain some of the symptoms of neurolathyrism.