The structure of the S-layer of Clostridium difficile.
The structure of the S-layer of Clostridium difficile.
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DOI：
10.1007/s12079-017-0429-z
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发表时间：
2018-03
影响因子：
4.1
通讯作者：
Acharya KR
中科院分区：
文献类型：
--
作者：
Bradshaw WJ;Roberts AK;Shone CC;Acharya KR
医院获得性病原体艰难梭菌（Clostridium difficile）是抗生素相关性腹泻的主要病原体，每年在全球造成数万人死亡。艰难梭菌在细胞表面呈现一种被称为s层的副晶蛋白阵列。s层已被证明具有广泛的重要功能，加上其固有的可及性，使其成为一个有希望的药物靶点。艰难梭菌异常复杂的s层主要由高分子量和低分子量的s层蛋白HMW SLP和LMW SLP组成，它们是由s层前体蛋白SlpA切割形成的，但也可能含有多达28个SlpA旁物。如果要利用s层来对抗细菌，就需要一个关于它如何作为一个整体发挥作用的模型。在这里，我们总结了艰难梭菌的s层和每个类似物的已知情况，并考虑到现有的一些结构域，提出了它们的潜在作用。
The nosocomially acquired pathogen Clostridium difficile is the primary causative agent of antibiotic associated diarrhoea and causes tens of thousands of deaths globally each year. C. difficile presents a paracrystalline protein array on the surface of the cell known as an S-layer. S-layers have been demonstrated to possess a wide range of important functions, which, combined with their inherent accessibility, makes them a promising drug target. The unusually complex S-layer of C. difficile is primarily comprised of the high- and low- molecular weight S-layer proteins, HMW SLP and LMW SLP, formed from the cleavage of the S-layer precursor protein, SlpA, but may also contain up to 28 SlpA paralogues. A model of how the S-layer functions as a whole is required if it is to be exploited in fighting the bacterium. Here, we provide a summary of what is known about the S-layer of C. difficile and each of the paralogues and, considering some of the domains present, suggest potential roles for them.
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影响因子：
3.1
作者：
Barkin, Jodie A.;Sussman, Daniel A.;Barkin, Jamie S.
通讯作者：
Barkin, Jamie S.
影响因子：
3
作者：
Brangulis, Kalvis;Jaudzems, Kristaps;Tars, Kaspars
通讯作者：
Tars, Kaspars
影响因子：
6.7
作者：
Chu, Michele;Mallozzi, Michael J. G.;Vedantam, Gayatri
通讯作者：
Vedantam, Gayatri
影响因子：
3.2
作者：
de la Riva, Luca;Willing, Stephanie E.;Fairweather, Neil F.
通讯作者：
Fairweather, Neil F.
DOI：
10.1111/febs.14310
发表时间：
2017-12
期刊：
The FEBS journal
影响因子：
--
作者：
Bradshaw WJ;Kirby JM;Roberts AK;Shone CC;Acharya KR
通讯作者：
Acharya KR