Species distribution and antifungal susceptibility among clinical isolates of Candida parapsilosis complex from India
Species distribution and antifungal susceptibility among clinical isolates of Candida parapsilosis complex from India
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DOI：
10.1016/j.riam.2018.01.004
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发表时间：
2018-07-31
影响因子：
1.9
通讯作者：
Biswas, Raja
中科院分区：
文献类型：
--
作者：
Maria, Susan;Barnwal, Gaurav;Biswas, Raja
背景资料：近平滑假丝酵母菌是一个种属复合体：近平滑假丝酵母菌、近平滑假丝酵母菌和偏平滑假丝酵母菌是3个不同但密切相关的种。方法：分离自临床标本的近平滑复合体。包括VITEK（R）2系统测定的近平滑综合征。使用VITEK（R）2半自动系统进行抗真菌药敏试验。结果：在77株C。近平滑复合体分离物、C.狭义近平滑线虫（57.1%）最常见，其次是C. orthosilosis（40.2%）和C.后移骨（2.5%）。所有三种菌种均对阿替霉素B、卡泊芬净和米卡芬净敏感。在C.对氟康唑耐药率为16%，敏感率为2.2%，呈剂量依赖性。C.严格意义上的近平滑体病分离株对伏立康唑的敏感性呈剂量依赖性。狭义近平滑病（parapsilosis sensu stricto）是最常见的分离型。对氟康唑高度耐药。C.还观察到骨化（40.2%）。(C)2018 Asociacion Espanola de Micologia.出版社：Elsevier Espana，S.L.U. All rights reserved.
Background: Candida parapsilosis is recognized as a species complex: Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis are three distinct but closely related species.Aims: To determine the species and antifungal susceptibility of members of the C. parapsilosis complex, isolated from clinical samples.Methods: Isolates identified as C. parapsilosis complex by VITEK (R) 2 system were included. Antifungal susceptibility test was done using the VITEK (R) 2 semi-automated system. The distribution of the species in the complex was determined by multiplex PCR.Results: Among the seventy-seven C. parapsilosis complex isolates, C. parapsilosis sensu stricto (57.1%) was the commonest species, followed by C. orthopsilosis (40.2%) and C. metapsilosis (2.5%). All three species were susceptible to amphotericin B, caspofungin and micafungin. Among C. parapsilosis sensu stricto isolates, 16% were resistant to fluconazole while 2.2% showed dose dependent susceptibility. Also, 18.2% of C. parapsilosis sensu stricto isolates showed dose dependent susceptibility to voriconazole.Conclusions: C. parapsilosis sensu stricto was the most commonly isolated member of the C. parapsilosis complex and it showed high resistance to fluconazole. A high prevalence of C. orthopsilosis (40.2%) was also noted. (C) 2018 Asociacion Espanola de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved.