Inflammation is detrimental for neurogenesis in adult brain
Inflammation is detrimental for neurogenesis in adult brain
复制标题
DOI：
10.1073/pnas.2234031100
复制
发表时间：
2003-11-11
影响因子：
11.1
通讯作者：
Lindvall, O
中科院分区：
文献类型：
--
作者：
Ekdahl, CT;Claasen, JH;Lindvall, O
新的海马神经元在成人大脑中不断产生。在这里，我们证明了脂多糖诱导的炎症，这引起了小胶质细胞的激活，在新的神经元出生的地区，强烈损害大鼠的基础海马神经发生。如果脑损伤引发的神经发生增加与组织损伤或脂多糖输注引起的小胶质细胞活化有关，则其也会减弱。全身给予米诺环素可抑制小胶质细胞活化，从而恢复炎症中受损的神经发生。我们的数据提高了激活的小胶质细胞抑制海马神经发生有助于衰老，痴呆，癫痫和其他导致脑炎症的疾病中的认知功能障碍的可能性。
New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats. The increased neurogenesis triggered by a brain insult is also attenuated if it is associated with microglia activation caused by tissue damage or lipopolysaccharide infusion. The impaired neurogenesis in inflammation is restored by systemic administration of minocycline, which inhibits microglia activation. Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation.