Environmental regulation of T-cell function in mice: Group housing of males affects accessory cell function
Environmental regulation of T-cell function in mice: Group housing of males affects accessory cell function
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DOI：
10.1046/j.1365-2567.1997.00190.x
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发表时间：
1997-02-01
期刊：
影响因子：
6.4
通讯作者：
Sercarz, EE
中科院分区：
文献类型：
--
作者：
Grewal, IS;Heilig, M;Sercarz, EE
研究发现，关在笼子里的小鼠的数量对雄性小鼠的免疫功能产生了重大影响。对鸡溶菌酶(HEL)免疫的C57BL/6雄性小鼠的淋巴结细胞进行了T细胞增殖反应的检测。群居男性的反应明显低于年龄匹配的女性。然而，在单独居住4-15周的男性中，反应相当高，接近女性对照组。为了检测宿主效应的细胞作用部位，检测了脾抗原提呈细胞(APC)的效率。成群雄性的APC比雌性的APC的效率低得多，而单独居住的雄性APC功能增强，达到雌性水平。我们的结果表明，环境操纵可以深刻地调节细胞免疫，并提供了第一个机械迹象，即APC功能是这种调节的主要靶点。
The number of mice housed in a cage was found to exert a major impact on immune function in male mice. Lymph node cells from hen lysozyme (HEL)-primed C57BL/6 male mice, housed in groups of 6/cage or individually, were tested for T-cell proliferative response. Group-housed males showed markedly lower responses than age-matched females. However, in males housed singly for 4-15 weeks, responses were considerably higher, approaching those of female controls. To examine the cellular site of action of the housing effect, the efficiency of splenic antigen-presenting cells (APC) was examined. APC from grouped males were considerably less efficient than APC from females, whereas males housed singly had increased APC function, reaching female levels. Our results demonstrate that environmental manipulation can profoundly modulate cellular immunity, and provide a first mechanistic indication that APC function is a major target for this modulation.