Drug-based helminth control in Western Pacific countries: a general perspective
Drug-based helminth control in Western Pacific countries: a general perspective
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DOI：
10.1046/j.1365-3156.2001.00820.x
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发表时间：
2001-11-01
影响因子：
3.3
通讯作者：
Palmer, K
中科院分区：
文献类型：
--
作者：
Urbani, C;Palmer, K
蠕虫病仍然在大量人群的健康中具有相关的有害作用。在卫生条件差、缺乏教育、保健服务和基本护理的地方，寄生虫感染严重影响个人生活的基本方面，如营养、认知能力、感染易感性和微量营养素缺乏症。严重的疾病与血吸虫病、淋巴丝虫病和食源性吸虫感染有关。药物是控制此类感染战略的基石，世界卫生组织（世卫组织）的基本药物清单包含几种高效驱虫药，它们都是安全、单剂量和廉价的。如果定期向受感染的社区提供这些药物，可有效控制与主要地方性蠕虫感染有关的发病率。对人口大规模用药的新战略已经过试验，西太平洋的几个流行国家在降低发病率方面取得了出色的成果，尽管疾病仍在继续传播。在该区域，过去几十年的经验证明了蠕虫控制的可行性，但也表明需要长期承诺和持续支持。
Helminthiases still have a relevant detrimental role in the health of large groups of human population. Where poor hygiene and lack of access to education, health services and essential care characterize living conditions, parasitic infections dramatically affect essential aspects of individual life, such as nutrition, cognitive performance, susceptibility to infections and micronutrient deficiency. Severe illness is associated with schistosomiasis, lymphatic filariasis and food-borne trematode infections. Drugs are the cornerstone of control strategies for such infections, the World Health Organization (WHO) list of essential drugs contains several highly efficacious anthelmintics which are all safe, single-dose and cheap. If given regularly to infected communities, these drugs effectively control the morbidity related to the major endemic helminth infections. New strategies for mass drug administration to human populations have been tested, and several endemic Western Pacific countries have achieved excellent results in reducing morbidity in spite of continuous transmission. In this region, experience over the last decades proves the feasibility of helminth control, but also shows the need for long-term commitment and continuous support.