In Reply: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation.
In Reply: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation.
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回复：网络靶向神经精神深部脑刺激的新框架。
DOI：
10.1093/neuros/nyab308
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发表时间：
2021
期刊：
影响因子：
4.8
通讯作者：
Sheth,SameerA
中科院分区：
文献类型：
--
作者：
Allawala,Anusha;Bijanki,KellyR;Goodman,Wayne;Cohn,JeffreyF;Viswanathan,Ashwin;Yoshor,Daniel;Borton,DavidA;Pouratian,Nader;Sheth,SameerA
正如我们的论文所述，以及Brown等人的评论所强调的，DBS正越来越多地用于各种神经系统疾病。然而，尽管DBS疗法的应用有很多机会，但我们必须承认，正在进行的DBS治疗这些无数疾病的试验结果显示出喜忧参半的结果。使用DBS改善或“神经增强”的一个关键限制是对正在治疗的疾病背后功能失调网络的神经动力学的不完全理解。虽然在了解帕金森病等运动障碍的神经相关性方面已经取得了实质性进展，但对精神疾病的神经生理学的类似程度的深入了解在很大程度上仍有待完成。在实现这种必要的网络级理解的许多方法中，我们的文章描述了一个我们认为对神经调节社区有用的平台。作为癫痫手术方法的自然延伸，它为该领域所熟悉，可以根据需要进行调整，以适应每个特定的新应用。我们再次感谢Brown等人对这篇文章的兴趣，并邀请其他人与我们联系，表达他们的想法。
As stated in our paper, 2 and as emphasized by the commentary from Brown et al, 1 DBS is being increasingly used for various neurological disorders. However, while there exist plentiful opportunities for the application of DBS therapy, we must acknowledge that results from ongoing trials with DBS therapy for these myriad disorders have shown mixed results. A critical limitation of using DBS for improvement or “neuroenhancement” is the incomplete understanding of the neural dynamics of the dysfunctional network (s) underlying the disease being treated. While there has been substantial progress in understanding neural correlates of movement disorders such as Parkinson’s disease, a similar degree of robust understanding of the neurophysiology of psychiatric disorders largely remains to be accomplished.Of the many ways to accomplish this necessary network-level understanding, our article describes one platform that we feel would be of use to the neuromodulation community. As a natural extension of the epilepsy surgery approach, it is familiar to the field and can be adapted as needed for each specific new application. We once again thank Brown et al for their interest in this article and invite others to contact us with their thoughts as well.