Infections in patients with chronic kidney disease
Infections in patients with chronic kidney disease
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DOI：
10.1016/j.idc.2007.06.005
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发表时间：
2007-09-01
影响因子：
4.4
通讯作者：
Foley, Robert N.
中科院分区：
文献类型：
--
作者：
Foley, Robert N.
关于晚期慢性肾脏病患者的重大感染的研究活动明显缺乏。对于一个局外人来说，这似乎是出乎意料的，因为尿毒症长期以来一直被认为是一种免疫反应低下的状态，并且已知透析人群中主要细菌感染（如败血症和肺炎）的发生率比普通人群高出几个数量级。本文回顾了最近的文献，主要集中在透析患者的主要细菌感染的临床流行病学，细菌感染和心血管疾病之间的联系，以及旨在预防这些感染的干预措施的随机试验。
There has been a notable lack of research activity regarding major infections in patients with advanced chronic kidney disease. To an outsider, this might seem unexpected, because uremia has long been considered a state of immune hyporesponsiveness and rates of major bacterial infection, like septicemia and pneumonia, are known to be orders of magnitude more likely in dialysis populations than in the general population. This article reviews recent literature on the topic, focusing predominantly on the clinical epidemiology of major bacterial infections in dialysis patients, the links between bacterial infections and cardiovascular disease, and randomized trials of interventions designed to prevent these infections.