Decreasing prevalence in cerebral palsy: a multi-site European population-based study, 1980 to 2003
Decreasing prevalence in cerebral palsy: a multi-site European population-based study, 1980 to 2003
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DOI：
10.1111/dmcn.12865
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发表时间：
2016-01-01
影响因子：
3.8
通讯作者：
Cans, Christine
中科院分区：
文献类型：
--
作者：
Sellier, Elodie;Platt, Mary Jane;Cans, Christine
目的监测1980~2003年欧洲地区出生体重脑性瘫痪(CP)患病率的变化趋势。方法收集20份欧洲脑性瘫痪监测资料。对4个出生体重组进行趋势分析：极低出生体重组为1000g，极低出生体重组为1000~1499g，中度低出生体重组为1500~2499g，正常出生体重组为2499g。结果CP总患病率从1.9‰下降到1.77‰，P<；0.001，年平均下降0.7%(95%可信区间为-0.3%~-1.0%)。NBW儿童的患病率从每1000名活产1.17人增加到0.89人，趋势不明显(p=0.22)。大规模出生体重儿的患病率从每1000名活产儿中的8.5‰下降到6.2‰(p<；0.001)，但不是线性的。极低出生体重儿的患病率也从70.9‰下降到35.9‰(P<；0.001)，年平均下降3.4%(95%可信区间-2.4%到-4.3%)。极低出生体重儿的患病率保持稳定，平均为每1000名活产儿中有42.4名。第一次，MLBW的患病率也出现了显著下降，导致CP患病率总体显著下降。
AIM To monitor the trends in prevalence of cerebral palsy (CP) by birthweight in Europe, 1980 to 2003.METHOD Data were collated from 20 population-based registers contributing to the Surveillance of Cerebral Palsy in Europe database. Trend analyses were conducted in four birthweight groups: < 1000g (extremely low birthweight [ELBW]); 1000 to 1499g (very low birthweight [VLBW]); 1500 to 2499g (moderately low birthweight [MLBW]); and > 2499g (normal birthweight [NBW]).RESULTS The overall prevalence of CP decreased from 1.90 to 1.77 per 1000 live births, p< 0.001, with a mean annual fall of 0.7% (95% confidence interval [CI] -0.3% to -1.0%). Prevalence in NBW children showed a non-significant trend from 1.17 to 0.89 per 1000 live births (p=0.22). Prevalence in MLBW children decreased from 8.5 to 6.2 per 1000 live births (p< 0.001), but not linearly. Prevalence in VLBW children also declined from 70.9 to 35.9 per 1000 live births (p< 0.001) with a mean annual fall of 3.4% (95% CI -2.4% to -4.3%). Prevalence in ELBW children remained stable, at a mean rate of 42.4 per 1000 live births.INTERPRETATION The decline in prevalence of CP in children of VLBW continues, and confirms that previously reported. For the first time, there is also a significant decline among those of MLBW, resulting in a significant overall decrease in the prevalence of CP.