Cell cycle-dependent regulation of cytoglobin by Skp2
Cell cycle-dependent regulation of cytoglobin by Skp2
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DOI：
10.1002/1873-3468.12864
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发表时间：
2017-11-01
期刊：
影响因子：
3.5
通讯作者：
Nag, Alo
中科院分区：
文献类型：
--
作者：
John, Rince;Atri, Yama;Nag, Alo
细胞珠蛋白（Cytoglobin，Cygb）是属于珠蛋白家族的一种细胞血红蛋白，其生物学功能尚不明确。Cygb在许多癌症中的下调表明其肿瘤抑制作用。这是首次报道Cygb对细胞周期的调控，发现Cygb在G1期达到峰值，在S期迅速下降。重要的是，Skp2介导的Cygb降解被鉴定为在细胞周期期间控制其振荡水平的关键机制。此外，Cygb的过表达刺激Rb的低磷酸化，导致细胞周期进展延迟。总的来说，这项研究揭示了Cygb表达调控的新机制，并赋予Cygb在细胞周期控制中的新作用。
Cytoglobin (Cygb) is a cellular haemoprotein belonging to the globin family with ambiguous biological functions. Downregulation of Cygb in many cancers is indicative of its tumour-suppressive role. This is the first report showing the cell cycle regulation of Cygb, which was found to peak at G1 and rapidly decline in S phase. Importantly, Skp2-mediated degradation of Cygb was identified as the key mechanism for controlling its oscillating levels during the cell cycle. Moreover, overexpression of Cygb stimulates hypophosphorylation of Rb causing delayed cell cycle progression. Overall, the study reveals a novel mechanism for the regulated expression of Cygb and also assigns a new role to Cygb in cell cycle control.