Direct organocatalytic coupling of carboxylated piperazine-2,5-diones with indoles through conjugate addition of carbon nucleophiles to indolenine intermediates.
Direct organocatalytic coupling of carboxylated piperazine-2,5-diones with indoles through conjugate addition of carbon nucleophiles to indolenine intermediates.
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DOI：
10.1016/j.tetlet.2009.11.068
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发表时间：
2010-01-27
影响因子：
1.8
通讯作者：
Olenyuk, Bogdan
中科院分区：
文献类型：
--
作者：
Dubey, Ramin;Olenyuk, Bogdan
The indole–diketopiperazine bridge is an important structural feature of many bispyrrolidinoindoline and epipolythiodiketopiperazine fungal metabolites. Organocatalytic conjugate addition of diketopiperazines to indoles was achieved in good to excellent yields through electrophilic indolenine intermediates generated under mild conditions. Screening of catalysts and solvents at different temperatures was performed in order to achieve high product yields.
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影响因子：
15
作者：
HENRY, DW;LEETE, E
通讯作者：
LEETE, E
影响因子：
16.6
作者：
Shaikh, Rafik R.;Mazzanti, Andrea;Melchiorre, Paolo
通讯作者：
Melchiorre, Paolo
影响因子：
1.8
作者：
Dubey, Ramin;Polaske, Nathan W.;Nichol, Gary S.;Olenyuk, Bogdan
通讯作者：
Olenyuk, Bogdan
DOI：
10.1126/science.1170777
发表时间：
2009-04-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kim J;Ashenhurst JA;Movassaghi M
通讯作者：
Movassaghi M
影响因子：
3.6
作者：
BARROW, CJ;CAI, P;COOPER, R
通讯作者：
COOPER, R