Prognostic impact of the controlling nutritional status score in patients with peripheral T-cell lymphoma
Prognostic impact of the controlling nutritional status score in patients with peripheral T-cell lymphoma
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DOI：
10.1080/10428194.2021.2020777
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发表时间：
2021-12-29
影响因子：
2.6
通讯作者：
Shimizu, Masahito
中科院分区：
文献类型：
--
作者：
Nakamura, Nobuhiko;Kanemura, Nobuhiro;Shimizu, Masahito
控制营养状态（CONUT）评分是根据血清白蛋白、总胆固醇和总淋巴细胞计数计算的简化营养指数。本研究评价了CONUT评分对外周T细胞淋巴瘤（PTCL）患者总生存期（OS）的预后影响。进行了一项包括99例PTCL患者的多中心、回顾性队列研究。非幸存者组的CONUT评分（中位数5，范围0-12）显著高于幸存者组（中位数3，范围0-11; p = 0.026）。在多变量考克斯比例风险模型中，CONUT评分是一个独立的预后因素（风险比1.119，95%置信区间1.021-1.227，p = 0.017）。没有观察到国际预后指数（IPI）的显著效应修正，并且无论IPI如何，CONUT评分都会影响PTCL的预后（相互作用P = 0.208）。总之，CONUT评分是PTCL的独立预后因素，与IPI分类无关。
The controlling nutritional status (CONUT) score is a simplified nutritional index calculated from serum albumin, total cholesterol, and total lymphocyte count. This study evaluated the prognostic impact of the CONUT score on overall survival (OS) in patients with peripheral T-cell lymphoma (PTCL). A multicenter, retrospective cohort study including 99 patients with PTCL was conducted. The CONUT score was significantly higher in the non-survivor group (median 5, range 0-12) than in the survivor group (median 3, range 0-11; p = 0.026). The CONUT score was an independent prognostic factor in a multivariable Cox proportional hazards model (hazard ratio 1.119, 95% confidence interval 1.021-1.227, p = 0.017). No significant effect-modification by the International Prognostic Index (IPI) was observed, and the CONUT score affected the prognosis of PTCL regardless of the IPI (P for interaction = 0.208). In conclusion, the CONUT score is an independent prognostic factor for PTCL irrespective of IPI category.