TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor
TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor
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DOI：
10.1515/jpme.1998.26.1.17
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发表时间：
1998-01-01
影响因子：
2.4
通讯作者：
Austgulen, R
中科院分区：
文献类型：
--
作者：
Arntzen, KJ;Kjollesdal, AM;Austgulen, R
炎症细胞因子似乎在分娩启动机制中起关键作用。由于早产时细胞因子水平高于足月产，有人假设在妊娠早期，细胞因子拮抗剂（如可溶性细胞因子受体）产生上调抑制了细胞因子的引产作用。在这项研究中，对以下三组人群的羊水样本中的肿瘤坏死因子（TNF）、白细胞介素 - 1（IL - 1）、白细胞介素 - 6（IL - 6）、白细胞介素 - 8（IL - 8）和可溶性肿瘤坏死因子受体（sTNFRs）进行了检测：a）39名早产临产的妇女；b）25名未临产但早产的妇女；c）33名足月临产的妇女。对54例早产胎盘进行了组织学绒毛膜羊膜炎的评估。绒毛膜羊膜炎与TNF、IL - 1和IL - 6水平升高有关，而在无感染迹象的早产中发现IL - 1、IL - 6和IL - 8浓度升高。早产时sTNFR浓度低于足月产。本研究证实了炎症细胞因子参与分娩。多变量分析表明，在绒毛膜羊膜炎存在的情况下，IL - 1起主要作用，而在特发性早产期间，IL - 6似乎更为重要。TNFR数据不支持细胞因子拮抗剂的产生在早产时上调以阻止分娩这一假设。
Inflammatory cytokines seem to play a key role in mechanisms initiating labor. Since cytokine levels are higher in preterm than in term labor, it has been hypothesized that labor-inducing effects of cytokines are inhibited by an upregulated production of cytokine antagonists, such as soluble cytokine receptors, at early stages of gestation. In this study, TNF, IL-1, IL-6, IL-8 and soluble TNF receptors (sTNFRs) were measured in amniotic fluid samples from a 39 women in premature labor, b) 25 women who where not in labor but delivered prematurely, and c) 33 women in term labor, Fifty-four of the placentas from premature deliveries were evaluted for presence of histological chorioamnionitis. Chorioamnionitis was associated with increased levels of TNF, IL-1 and IL-6, whereas elevated IL-1, IL-6 and IL-8 concentrations were found in premature parturition with no signs of infection. Concentrations of sTNFR were lower in preterm than in term deliveries. The present study confirms the participation of inflammatory cytokines in parturition. Multivariate analysis suggests a dominant role of IL-1 in the presence of choriao-amnionitis, whereas IL-6 seems to be more important during idiopathic premature labor, TNFR data do not support the hypothesis that production of cytokine antagonists is upregulated prematurely to prevent partirution.