CLINICAL RESULTS OF A CROSSOVER TREATMENT WITH PYRIDOXINE AND PLACEBO OF THE CARPAL-TUNNEL SYNDROME
CLINICAL RESULTS OF A CROSSOVER TREATMENT WITH PYRIDOXINE AND PLACEBO OF THE CARPAL-TUNNEL SYNDROME
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DOI：
10.1093/ajcn/32.10.2040
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发表时间：
1979-01-01
影响因子：
7.1
通讯作者：
WOOD, FS
中科院分区：
文献类型：
--
作者：
ELLIS, J;FOLKERS, K;WOOD, FS
对22例腕管综合征患者进行了吡哆醇和安慰剂交叉治疗的临床评估。对红细胞谷草转氨酶的特殊活性的特殊监测证明，这是一种严重的维生素B6缺乏症，通过推荐的2毫克膳食供给量[RDA]部分纠正，并通过100毫克完全纠正。在RDA上，综合征的严重程度减轻，患者在较高剂量时没有症状。服用安慰剂的人再次出现维生素B6缺乏和症状。再用100 mg纠正虚证。用测角器测量(19)食指近端指间关节屈曲，用Preston规测量收缩(19)，显示客观正常化。17种症状的评分显示，在2毫克(P<；0.001)和100 mg(P<；0.001)剂量下，症状有所减轻。通过肌电图术，腕管的传导得到了改善。伴发维生素B6缺乏症和腕管综合征之间存在明显的因果关系。
Clinical evaluation was made of crossover treatments by pyridoxine and a placebo of 22 patients having the carpal tunnel syndrome. Extraordinary monitoring of the specific activities of the erythrocyte glutamic oxaloacetic transaminase proved a severe vitamin B6 deficiency which was partially corrected by the Recommended Dietary Allowance [RDA] of 2 mg and completely corrected by 100 mg. The severity of the syndrome diminished on the RDA and the patient was asymptomatic at the higher dosage. On placebo the vitamin B6 deficiency and syndrome reappeared. Retreatment with 100 mg corrected the deficiency and syndrome. Measurements (19) of flexion of proximal interphalangeal joints of the index fingers by a goniometer and of pinch by the Preston gauge revealed objective normalization. Scores of 17 symptoms revealed reductions at the 2 (P < 0.01) and 100 mg (P < 0.001) dosages. Conduction through the carpal tunnels had improved by electromyography. A causal relationship is apparent between the concomitant presence of a vitamin B6 deficiency and the carpal tunnel syndrome.