Synthesis of Backbone Thermo and pH Dual-Responsve Hyperbranched Poly(amine-ether)s Through Proton-Transfer Polymerization
Synthesis of Backbone Thermo and pH Dual-Responsve Hyperbranched Poly(amine-ether)s Through Proton-Transfer Polymerization
复制标题
通过质子转移聚合合成骨架热和pH双响应超支化聚（胺-醚）
DOI：
10.1002/pola.24509
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发表时间：
2011-02-15
影响因子：
--
通讯作者：
Zhu, Bangshang
中科院分区：
文献类型：
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作者：
Pang, Yan;Zhu, Qi;Zhu, Bangshang
刺激响应型超支化聚合物由于在生物医学领域的广泛应用，近年来引起了人们的广泛关注。以三乙醇胺和1，2，7，8-二环氧辛烷为原料，在氢化钾的作用下进行质子转移聚合，一锅法合成了一系列新型主链温度和pH双重响应的超支化聚（胺-醚）。所得聚合物的支化度为0.40-0.49。湍流测量结果表明，超支化聚（胺醚）在水中表现出温度和pH值的双重响应性能。重要的是，这些响应度可以通过改变聚合物组成以及水溶液中的聚合物浓度来容易地调节。此外，在体外评价表明，超支化聚（胺-醚）s显示出低细胞毒性和有效的细胞内化对NIH 3 T3细胞系。这些结果表明，这些主链的温度和pH双重响应的超支化聚（胺-醚）是有前途的生物医学材料。© 2010 Wiley Periodicals，Inc.聚合物科学杂志A部分：聚合物化学，2011年
Stimuli-responsive hyperbranched polymers have attracted great attention in recent years because of their wide applications in biomedicine. Through proton-transfer polymerization of triethanolamine and 1,2,7,8-diepoxyoctane with the help of potassium hydride, a series of novel backbone thermo and pH dual-responsive hyperbranched poly(amine-ether)s were prepared successfully in one-pot. The degrees of branching of the resulting polymers were at 0.40–0.49. Turbidity measurements revealed that hyperbranched poly(amine-ether)s exhibited thermo and pH dual-responsive properties in water. Importantly, these responsivities could be readily adjusted by changing the polymer composition as well as the polymer concentration in aqueous solution. Moreover, in vitro evaluation demonstrated that hyperbranched poly(amine-ether)s showed low cytotoxicity and efficient cell internalization against NIH 3T3 cell lines. These results suggest that these backbone thermo and pH dual-responsive hyperbranched poly(amine-ether)s are promising materials for biomedicine. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011