Operant reward learning in Aplysia:: Neuronal correlates and mechanisms
Operant reward learning in Aplysia:: Neuronal correlates and mechanisms
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DOI：
10.1126/science.1069434
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发表时间：
2002-05-31
期刊：
影响因子：
56.9
通讯作者：
Byrne, JH
中科院分区：
文献类型：
--
作者：
Brembs, B;Lorenzetti, FD;Byrne, JH
操作性条件反射是一种联想学习的形式，通过它，动物了解其行为的后果，在这里，我们报告了一个食欲的操作性条件反射程序，在Aaplasia诱导长期记忆。伴随着记忆的生物物理变化被发现在一个被识别的神经元（细胞B51）中，该神经元被认为是表达奖励行为的关键。类似的细胞变化B51产生的应急加强B51与多巴胺在单细胞模拟的操作程序。这些发现允许详细分析的细胞和分子过程的基础操作性条件反射。
Operant conditioning is a form of associative learning through which an animal learns about the consequences of its behavior, Here, we report an appetitive operant conditioning procedure in Aplysia that induces long-term memory. Biophysical changes that accompanied the memory were found in an identified neuron (cell B51) that is considered critical for the expression of behavior that was rewarded. Similar cellular changes in B51 were produced by contingent reinforcement of B51 with dopamine in a single-cell analog of the operant procedure. These findings allow for the detailed analysis of the cellular and molecular processes underlying operant conditioning.