Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer
Quantitative correlation between 1H MRS and dynamic contrast-enhanced MRI of human breast cancer
复制标题
DOI：
10.1016/j.mri.2007.10.002
复制
发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Su, Min-Ying
中科院分区：
文献类型：
--
作者：
Baek, Hyeon-Man;Yu, Hon J.;Su, Min-Ying
质子磁共振波谱（H MRS）和动态对比增强（DCE）磁共振成像（MRI）提供功能信息，包括血管容积、血管通透性和胆碱（Cho）代谢。在本研究中，我们应用这两种成像模式来定量表征32例患者的36个恶性乳腺病变，并分析它们之间的相关性。Cho浓度通过使用水作为内部参考的单体素H-1 MRS定量。测得的Cho水平范围为0.32至10.47 mmol/kg，与先前报告的值一致。在25个肿块型病灶中，Cho浓度与肿瘤大小显著相关（r= 0.69，P
Proton magnetic resonance spectroscopy (H MRS) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) provide functional information, including vascular volume, vascular permeability and choline (Cho) metabolism. In this study, we applied these two imaging modalities to quantitatively characterize 36 malignant breast lesions in 32 patients and analyzed the correlation between them. Cho concentration was quantified by single-voxel H-1 MRS using water as an internal reference. The measured Cho levels ranged from 0.32 to 10.47 mmol/kg, consistent with previously reported values. In 25 mass-type lesions, the Cho concentration was significantly correlated with tumor size (r=.69, P