Outcome in children with fetal mild ventriculomegaly: a case series
Outcome in children with fetal mild ventriculomegaly: a case series
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DOI：
10.1016/s0920-9964(00)00140-7
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发表时间：
2001-03-30
影响因子：
4.5
通讯作者：
Chescheir, NC
中科院分区：
文献类型：
--
作者：
Gilmore, JH;van Tol, JJ;Chescheir, NC
侧脑室轻度增大与精神分裂症和其他神经发育障碍有关。虽然有假设认为脑室异常与胎儿大脑发育过程中出现的神经发育障碍有关，但几乎没有直接证据支持这一假设。胎儿轻度脑室肿大（MVM）与儿童早期发育迟缓有关，但长期的神经发育结果尚未研究。本文报道了5名产前超声显示侧脑室轻度增大的儿童（4-9岁）和2名未受影响的双胞胎的随访：1名儿童患有注意缺陷多动障碍（ADHD）， 1名患有自闭症，2名有学习障碍的证据。这些病例表明，与这些神经发育障碍相关的侧脑室轻度扩大出现在胎儿大脑发育期间，可以通过产前超声检测到。此外，两名儿童在6岁时的产前超声和随访MRI中发现轻度增大的不对称脑室，这表明子宫内的脑室结构可以持续到儿童大脑发育。利用超声对胎儿脑室发育的研究可能为神经发育障碍提供重要的见解，并允许识别高危儿童。(C) 2000 Elsevier Science B.V.版权所有
Mild enlargement of the lateral ventricles is associated with schizophrenia and other neurodevelopmental disorders. While it has been hypothesized that ventricle abnormalities associated with neurodevelopmental disorders arise during fetal brain development, there is little direct evidence to support this hypothesis. Using ultrasound, it is possible to image the fetal ventricles in utero, Fetal mild ventriculomegaly (MVM) has been associated with developmental delays in early childhood, though longer-term neurodevelopmental outcome has not been studied. Follow-up of five children (aged 4-9 years) with mild enlargement of the lateral ventricles on prenatal ultrasound and two unaffected co-twins is reported: one child had attention deficit hyperactivity disorder (ADHD), one had autism, and two had evidence of learning disorders. These cases suggest that the mild enlargement of the lateral ventricles associated with these neurodevelopmental disorders arises during fetal brain development and can be detected with prenatal ultrasound. In addition, the presence of mildly enlarged, asymmetric ventricles in two children on prenatal ultrasound and on follow-up MRI at age 6 years indicates that ventricle structure present in utero can persist well into childhood brain development. The study of fetal ventricle development with ultrasound may provide important insights into neurodevelopmental disorders and allow the identification of children at high risk. (C) 2000 Elsevier Science B.V. All rights reserved.