ACUTE-PHASE PROTEINS IN ALZHEIMERS-DISEASE
ACUTE-PHASE PROTEINS IN ALZHEIMERS-DISEASE
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DOI：
10.1159/000116224
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发表时间：
1988-01-01
影响因子：
2.4
通讯作者：
TAVOLATO, B
中科院分区：
文献类型：
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作者：
GIOMETTO, B;ARGENTIERO, V;TAVOLATO, B
测定了20例老年前期阿尔茨海默病（AD）患者血清中主要的急性时相蛋白，并与18例年龄匹配的健康对照者进行了比较。评价了以下参数：α 1-抗胰蛋白酶α AT）、触珠蛋白（HPT）、转铁蛋白（TRF）、酸性α 1-糖蛋白（A α G）、血浆铜蓝蛋白（CER）、α 2-巨球蛋白（α MG）、C-反应蛋白（CRP）、白蛋白（ALB），以及免疫球蛋白IgG、IgM和伊加，以及经典的一些最重要的因子（C3，C4）和补体激活的替代（备解素因子B）途径。结果显示α AT（p < 0.001）、CER（p <0.001）和所有研究的补体因子（p < 0.005）的水平在统计学上显著增加。其他急性期蛋白（HPT、TRF、A α G、α MG、CRP、ALB）和免疫球蛋白（IgG、IgM、伊加）的水平在AD患者和正常对照中相似。这些结果产生了这样的可能性，即这些元素指示与慢性细胞损伤和/或慢性炎症状况相容的改变的免疫调节。此外，α AT水平的增加可能与AD中报道的白细胞介素-1（IL-1）的低产生有关，这支持了早老性AD患者中巨噬细胞功能相对紊乱的假设。
The main ''acute-phase proteins'' were determined in serum of 20 patients with presenile Alzheimer''s disease (AD) and compared with values in 18 age-matched healthy control subjects. Following parameters were evaluated: .alpha.1-antitrypsin (.alpha.AT), haptoglobin (HPT), transferrin (TRF), acidic .alpha.1-glycoprotein (A.alpha.G), ceruloplasmin (CER), .alpha.2-macroglobulin (.alpha.MG), C-reactive protein (CRP), albumin (ALB), together with the immunoglobulins IgG, IgM and IgA, and some of the most significant factors of the classic (C3, C4) and alternative (properdin factor B) pathways of complement activation. The results showed a statistically significant increase in the levels of .alpha.AT (p < 0.001), CER (p < 0.001) and of all the complement factors studied (p < 0.005). The levels of other acute-phase proteins (HPT, TRF, A.alpha.G, .alpha.MG, CRP, ALB) and immunoglobulins (IgG, IgM, IgA) were similar in AD patients and normal controls. These results give rise to the possibility that these elements indicate an altered immunoregulation compatible with chronic cell damage and/or chronic inflammation conditions. Moreover, the increased level of .alpha.AT can be related to the low production of interleukin-1 (IL-1) reported in AD, which supports the hypothesis of a relative derangement of the macrophage function in presenile AD patients.