Stem cells in gastrointestinal cancers: a matter of choice in cell fate determination
Stem cells in gastrointestinal cancers: a matter of choice in cell fate determination
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DOI：
10.1586/era.10.52
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发表时间：
2010-10
影响因子：
3.3
通讯作者：
B. Wei;Lin Chen;Rong Li;Jiahe Tian
中科院分区：
文献类型：
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作者：
B. Wei;Lin Chen;Rong Li;Jiahe Tian
癌性干细胞具有与正常干细胞相同的自我更新和分化特性，并且具有与从相同组织分离的成体干细胞相似的表型。一些人认为癌症干细胞是由正常干细胞突变而来，而另一些人则怀疑它们有不同的起源。虽然复杂和有争议，干细胞作为癌症的祖细胞在白血病研究中找到了支持，随后在一些实体瘤中找到了支持。首先接受的是，干细胞和祖细胞都可以获得遗传异常，这将导致不受控制的复制和失调的分化，导致它们转化为癌性干细胞，然后可能引发和维持肿瘤。在这篇文章中，我们讨论了在胃和肠道肿瘤干细胞的研究，同时专注于干细胞转化和胃肠道肿瘤发生的复杂的分子途径的最新进展。这种理解为有希望的新疗法提供了基础，这些疗法可能特异性靶向胃肠道癌干细胞。
Cancerous stem cells share the same properties of self-renewal and differentiation as normal stem cells, and have a similar phenotype to adult stem cells isolated from the same tissue. Some believe that cancer stem cells are derived from mutation of normal stem cells, whereas others suspect them to have different origins. Although complicated and controversial, the stem cell as the progenitor of cancer has found support in leukemia research, and subsequently in some solid tumors. It was first accepted that both stem and progenitor cells could acquire genetic abnormalities that would lead to uncontrolled replication and dysregulated differentiation, causing them to transform into cancerous stem cells that might then initiate and maintain a tumor. In this article, we discuss recent progress in the studies of stomach and intestinal cancer stem cells, while focusing on the complex molecular pathways underlying stem cell transformation and gastrointestinal tumorigenesis. This understanding provides a basis for promising new therapies that may specifically target gastrointestinal cancer stem cells.