Sucrose-induced obesity impairs novel object recognition learning in young rats
Sucrose-induced obesity impairs novel object recognition learning in young rats
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DOI：
10.1016/j.physbeh.2008.07.023
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发表时间：
2009-01-08
影响因子：
2.9
通讯作者：
Kanarek, Robin B.
中科院分区：
文献类型：
--
作者：
Jurdak, Nicole;Kanarek, Robin B.
除了代谢方面的影响，肥胖还可能导致学习和记忆能力受损。为了测试这种可能性，雄性Long-Evans大鼠被喂食磨碎的食物，或喂食含有32%蔗糖溶液或氢化植物脂肪（Crisco (R)）的食物八周。然后通过一项新的物体识别任务来评估认知行为。为了确定认知行为和葡萄糖代谢之间是否存在关系，研究人员将受试者在新物体识别任务中的表现与空腹血糖水平和口服葡萄糖耐量试验中的反应联系起来。喂食蔗糖或脂肪的老鼠比只喂食食物的老鼠消耗更多的卡路里，体重增加更多，附睾脂肪垫也更大。此外，空腹血糖水平和口服葡萄糖耐量试验后的葡萄糖曲线下面积，食用补充脂肪或蔗糖的大鼠比只吃食物的大鼠更高。在训练过程中，当大鼠在一个开阔的场地上看到两个相同的物体时，探索物体所花费的时间并没有因为饮食条件而有所不同。然而，当老鼠随后分别用一个熟悉的物体和一个新的物体进行测试时，喂食蔗糖的老鼠探索新物体的时间明显少于只吃食物的老鼠。探索新物体的时间百分比与空腹血糖水平、最终体重和附睾脂肪垫重量呈负相关。据推测，吃蔗糖的大鼠的物体识别能力受损，至少部分是由于饮食引起的葡萄糖代谢的改变。(C) 2008爱思唯尔公司版权所有。
In addition to its metabolic consequences, obesity may lead to impairments in learning and memory. To test this possibility, male Long-Evans rats were fed ground chow, or chow and either a 32% sucrose solution or hydrogenated vegetable fat (Crisco (R)) for eight weeks. Cognitive behavior was then assessed using a novel object recognition task. To determine if there was a relationship between cognitive behavior and glucose metabolism, performance on the novel object recognition task was correlated with fasting blood glucose levels and responses on an oral glucose tolerance test. Rats fed sucrose or fat consumed more calories, gained more weight, and had larger epididymal fat pads than rats fed only chow. Additionally, fasting blood glucose levels, and the area under the glucose curve following an oral glucose tolerance test were greater in rats consuming a supplemental source of fat or sucrose than in those eating only chow. During training when rats were presented with two identical objects in an open field, time spent exploring the objects did not differ as a function of dietary conditions. However, when rats were tested I h later with one familiar and one novel object, rats given sucrose spent significantly less time exploring the novel object than rats eating only chow. The percent of time spent exploring the novel object was negatively correlated with fasting blood glucose levels, final body weights, and epididymal fat pad weights. It is hypothesized that the impairment in object recognition in rats eating sucrose is due, at least in part, to diet-induced alterations in glucose metabolism. (C) 2008 Elsevier Inc. All rights reserved.