Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin.
Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin.
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DOI：
10.1016/j.canlet.2014.04.016
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发表时间：
2014-08-01
期刊：
影响因子：
9.7
通讯作者：
Mousa, Shaker A.
中科院分区：
文献类型：
--
作者：
Sudha, Thangirala;Yalcin, Murat;Lin, Hung-Yun;Elmetwally, Ahmed M.;Nazeer, Tipu;Arumugam, Thiruvengadam;Phillips, Patricia;Mousa, Shaker A.
关键词：
与低分子量肝素（LMWH）相比，硫酸化非抗凝肝素（S-NACH）可能是癌症患者潜在临床应用的首选，而不会影响止血。我们研究了S-NACH在胰腺癌小鼠模型中的抗肿瘤作用、抗血管生成作用和机制，并与LMWH汀扎肝素进行了比较。给予S-NACH或汀扎肝素（含或不含吉西他滨），并在研究结束时评估肿瘤发光信号强度、肿瘤重量和组织病理学。S-NACH和LMWH有效抑制肿瘤生长和转移，与汀扎肝素相比，S-NACH未观察到任何出血事件。在小鼠胰腺癌模型中，S-NACH明显增加肿瘤坏死并增强吉西他滨反应。这些数据表明S-NACH作为胰腺癌新辅助治疗的潜在意义。
Sulfated non-anticoagulant heparins (S-NACHs) might be preferred for potential clinical use in cancer patients without affecting hemostasis as compared to low molecular weight heparins (LMWHs). We investigated anti-tumor effects, anti-angiogenesis effects, and mechanisms of S-NACH in a mouse model of pancreatic cancer as compared to the LMWH tinzaparin. S-NACH or tinzaparin with or without gemcitabine were administered, and tumor luminescent signal intensity, tumor weight, and histopathology were assessed at the termination of the study. S-NACH and LMWH efficiently inhibited tumor growth and metastasis, without any observed bleeding events with S-NACH as compared to tinzaparin. S-NACH distinctly increased tumor necrosis and enhanced gemcitabine response in the mouse pancreatic cancer models. These data suggest the potential implication of S-NACH as a neoadjuvant in pancreatic cancer.
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1.8
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Mousa, Shaker A.
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