Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation.
Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation.
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Gankyrin 通过 mTORC1 激活驱动胃癌恶性转化并减轻氧化应激
DOI：
10.1155/2018/9480316
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发表时间：
2018
影响因子：
--
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Huang B;Cai W;Wang Q;Liu F;Xu M;Zhang Y
胃癌作为一种恶性上皮性肿瘤，是一种主要的健康威胁，导致总体生存率低和死亡。它通常是在晚期诊断，由于无症状或只有非特异性的早期症状。本研究表明，Gankyrin有助于胃癌的早期恶性转化，并可选择性地预测具有癌前病变（异型增生和肠上皮化生）的患者的胃癌风险。此外，还提供了对胃癌的新见解，即Gankyrin通过mTORC 1途径激活来减轻氧化应激。它可以通过PGK 1-AKT信号通路增强mTORC 1，促进肿瘤进程，这种现象与以前描述结直肠癌的报道不完全一致。
Gastric cancer, as a malignant epithelial tumor, is a major health threat leading to poor overall survival and death. It is usually diagnosed at an advanced stage due to asymptomatic or only nonspecific early symptoms. The present study demonstrated that gankyrin contributes to the early malignant transformation of gastric cancer and can be selected to predict the risk of gastric cancer in those patients harboring the precancerous lesions (dysplasia and intestinal metaplasia). In addition, a new insight into gastric cancer was provided, which stated that gankyrin alleviates oxidative stress via mTORC1 pathway activation. It can potentiate the mTORC1 by PGK1-AKT signaling that promotes the tumor process, and this phenomenon is not completely consistent with the previous report describing colorectal cancer.