GENERATION OF ALPHA-HYDROXYALDEHYDIC COMPOUNDS IN THE COURSE OF LIPID-PEROXIDATION
GENERATION OF ALPHA-HYDROXYALDEHYDIC COMPOUNDS IN THE COURSE OF LIPID-PEROXIDATION
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DOI：
10.1016/0005-2760(94)90020-5
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发表时间：
1994-07-14
期刊：
影响因子：
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通讯作者：
SPITELLER, G
中科院分区：
文献类型：
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作者：
LOIDLSTAHLHOFEN, A;HANNEMANN, K;SPITELLER, G
基于O-18标记实验，提出了亚油酸脂质过氧化过程中羟基类化合物生成的一般方案。关键中间体显然是双氧脂肪酸，因为在用NaBH 4或Rh/H-2还原后1，2。和1，6二羟基脂肪酸。该机理不仅解释了2-羟基烷醛的形成，而且支持了早期关于1-羟基烯醛生成的假说。此外，它预测的发生（n - 1）-羟基-n-氧代脂肪酸作为额外的氧化产物。对这些以前未知的亚油酸自氧化产物的研究确实是成功的。
Based on O-18-labeling experiments a general scheme for the generation of hydroxy aldehydic compounds in the course of lipid peroxidation of linoleic acid is developed. Key intermediates are obviously dioxygenated fatty acids, since after reduction with either NaBH4 or Rh/H-2 1,2. and 1,6 dihydroxy fatty acids can be identified. The postulated mechanism not only explains the formation of 2-hydroxyalkanals but also supports earlier hypothesis concerning the generation of 1-hydroxyalkenals. In addition it predicted the occurrence of (n - 1)-hydroxy-n-oxo fatty acids as additional oxidation products. A search for these previously unknown autoxidation products of linoleic acid was indeed successful.