Usage Data and Scientific Impact of the Prospectively Established Fluid Bioresources at the Hospital-Based MedUni Wien Biobank
Usage Data and Scientific Impact of the Prospectively Established Fluid Bioresources at the Hospital-Based MedUni Wien Biobank
复制标题
DOI：
10.1089/bio.2018.0032
复制
发表时间：
2018-10-18
影响因子：
1.6
通讯作者：
Perkmann, Thomas
中科院分区：
文献类型：
--
作者：
Haslacher, Helmuth;Gerner, Marlene;Perkmann, Thomas
背景和目的：人们越来越认识到，生物医学研究有严重的可重复性问题，这至少可以通过生物材料的标准化处理来部分克服。因此，出现了专业生物库，对样本和数据质量产生了积极影响。然而，关于生物库对已发表结果的贡献的定量数据仍然很难找到，尽管它们可以作为社区有价值的基准数据。因此，我们旨在报告MedUni Wien Biobank机构关于其前瞻性液体队列的使用数据。方法：报告2010 - 2017年的输入和访问统计数据以及出版物输出。根据斯皮尔曼的相关性分析测试性能动态。此外，还计算了每个样本的虚拟成本。结果如下：每年收集的等分试样数量从2010年的68，500份显著增加到2017年的151，966份（p = 0.015），尽管2012年后没有进一步增加（p = 0.266）。在同一时期，请求的等分试样与储存的等分试样的商从3.5%增加到6.1%（p = 0.001），因为每年请求的等分试样数量几乎翻了两番，从2401增加到9342。同样，MedUni Wien Biobank每年贡献的已发表研究文章数量从2010年的2篇（总影响因子：8.6）增加到2017年的16篇（总影响因子：69.0），共识别出69篇出版物。目前，生物库的生产过剩了15至20倍，导致每个获取样本的实际成本约为20欧元。结论：报告的使用数据可能作为其他医院综合生物库的基准，并意味着学术生物库能够产生相当大的科学影响，在相当温和的成本。
Background and Aim: It is increasingly recognized that biomedical research has serious reproducibility issues, which could be overcome at least in part by standardized processing of biomaterials. Therefore, professional biobanks have emerged, positively influencing sample and data quality. However, quantitative data about a biobank's contribution to published results are still hard to find, although they could serve as valuable benchmark figures for the community. We therefore aimed to report usage data from the MedUni Wien Biobank facility regarding its prospective fluid cohorts. Methods: Input and access statistics and publication output were reported for the years 2010-2017. Performance dynamics were tested by correlation analyses according to Spearman. Additionally, virtual costs per sample were calculated. Results: The amount of annually collected aliquots rose significantly from 68,500 in 2010 to 151,966 in 2017 (p=0.015), although no further increase was recorded after 2012 (p=0.266). In the same period, the quotient of requested to stored aliquots increased from 3.5% to 6.1% (p=0.001), as the yearly number of requested aliquots nearly quadrupled from 2401 to 9342. Likewise, the number of published research articles per year to which the MedUni Wien Biobank contributed increased from 2 (total impact factor: 8.6) in 2010 to 16 (total impact factor: 69.0) in 2017, resulting in a total of 69 identified publications. Currently, the biobank operates at 15- to 20-fold overproduction, leading to virtual costs per accessed sample of approximate to Euro20. Conclusion: The reported usage data might serve as a benchmark for other hospital-integrated biobanks, and implies that academic biobanks are able to produce considerable scientific impact at comparable moderate costs.