Silica decreases phagocytosis and bactericidal activity of both macrophages and neutrophils in vitro.
Silica decreases phagocytosis and bactericidal activity of both macrophages and neutrophils in vitro.
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DOI：
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发表时间：
1986-12
期刊：
影响因子：
6.4
通讯作者：
B. Zimmerman;B. Canono;P. Campbell
中科院分区：
文献类型：
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作者：
B. Zimmerman;B. Canono;P. Campbell
硅石或二氧化硅已被证明对巨噬细胞有毒。这可能是因为它会损害吞噬溶酶体膜，使溶酶体酶破坏细胞。中性粒细胞还吸收二氧化硅等颗粒，此外还含有溶酶体。本研究的目的是确定在体外与二氧化硅一起孵育是否不仅会抑制小鼠巨噬细胞的功能，还会抑制小鼠中性粒细胞的功能。数据显示，用二氧化硅孵育 1-3 小时会降低巨噬细胞和中性粒细胞的活力。二氧化硅降低巨噬细胞和中性粒细胞吞噬红细胞和细菌的能力，并抑制这两种细胞群杀死兼性细胞内细菌单核细胞增生李斯特氏菌的能力。因此，至少在体外，二氧化硅似乎对中性粒细胞和巨噬细胞有害。
Silica, or silicon dioxide, has been shown to be toxic for macrophages. This is probably because it damages phagolysosomal membranes, allowing lysosomal enzymes to disrupt the cell. Neutrophils also take up particles such as silica and in addition they contain lysosomes. The purpose of this study was to determine whether incubation in vitro with silica inhibits function not only of mouse macrophages, but also of mouse neutrophils. The data show that incubation with silica for 1-3 hr decreases viability of both macrophages and neutrophils. Silica decreases the ability of macrophages and neutrophils to phagocytose both erythrocytes and bacteria, and it inhibits the ability of both cells populations to kill the facultative intracellular bacterium Listeria monocytogenes. Thus, it appears that silica, at least in vitro, is harmful to neutrophils as well as to macrophages.