Evidence and mechanisms of immunosuppression in tick infestations
Evidence and mechanisms of immunosuppression in tick infestations
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DOI：
10.1016/s1050-3862(99)00017-0
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发表时间：
1999-11-01
期刊：
影响因子：
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通讯作者：
Barriga, OO
中科院分区：
文献类型：
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作者：
Barriga, OO
很久以前，蜱虫的丰富性和普遍性表明它们已经逃避了宿主免疫力。在过去的15年中，几位作者已经证明了在实验室和自然模型中蜱虫感染后，Th1应答（细胞介导的免疫）和有时Th2应答（体液免疫）受到抑制。虽然产生抑制的机制尚未明确，但已有证据表明抗原竞争、淋巴细胞细胞毒性、唾液中存在免疫抑制物质以及唾液提取物中存在细胞因子调节剂。蜱诱导的免疫抑制的管理是必不可少的替代蜱螨剂的应用与更环保的疫苗接种控制。(C)1999 Elsevier Science B.V.保留所有权利。
The abundance and ubiquity of ticks from ancient times long ago suggested that they have eluded host immunity. In the last 15 years, several authors have demonstrated suppression of the Th1 responses (cell-mediated immunity), and sometimes the Th2 responses (humoral immunity), subsequent to tick infestations in laboratory and natural models. Although the mechanisms to produce suppression ale nor well-defined yet, evidences for antigenic competition, lymphocyte cylotoxicity, presence of immuno-inhibiting substances ill the saliva, and existence of modulators of cytokines in salivary extracts have been reported. Management of tick-induced immunosuppression is essential to replace tick control by acaricide application with more environmentally sound vaccination. (C) 1999 Elsevier Science B.V. All rights reserved.