Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin
Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin
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DOI：
10.1136/gut.38.5.663
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发表时间：
1996-05-01
期刊：
影响因子：
24.5
通讯作者：
Baron, JH
中科院分区：
文献类型：
--
作者：
Harris, AW;Gummett, PA;Baron, JH
背景-十二指肠溃疡（DU）患者具有高基础（BAO）和峰值（PAO）酸排出量。幽门螺杆菌根除对这些变量的影响尚不清楚。目的-发现DU患者的胃酸分泌过多是否由幽门螺杆菌引起。患者和方法-BAO，胃泌素释放肽（GRP），五肽胃泌素刺激的PAO在10个幽门螺杆菌阴性对照组，并在10个幽门螺杆菌阳性DU患者幽门螺杆菌根除前和6个月后测定。幽门螺杆菌状态通过组织学、培养和C-13-尿素呼气试验确定。在收集30分钟的基础抽吸物后，GRP 40 pmol/kg/h输注45分钟，并且在30分钟的冲洗后，pentagastrin 6 μ g/kg被肌肉注射intramically.Results-Basal和刺激的酸输出（PAO（GRP）和PAO（Pg））在H pylori阳性DU中显著高于H pylori阴性对照。幽门螺杆菌根除后6个月，基础和刺激酸输出均显着低于前幽门螺杆菌根除。结论这项研究表明，BAO，PAO（GRP），PAO（PG）是高于幽门螺杆菌阳性DU比幽门螺杆菌阴性对照。幽门螺杆菌根除后6个月，所有指标均显著下降，落在对照组范围内。这些结果与幽门螺杆菌感染引起十二指肠溃疡病酸分泌过多的假设是一致的。
Background-Patients with duodenal ulcer (DU) have high basal (BAO) and peak (PAO) acid outputs. The effect of Helicobacter pylori eradication on these variables is unclear.Aim-To discover if gastric acid hypersecretion in patients with DU is caused by H pylori.Patients and methods-BAO, gastrin releasing peptide (GRP), and pentagastrin stimulated PAO in 10 H pylori negative controls, and in 10 Hpylori positive patients with DU was measured before and six months after H pylori eradication. H pylori status was determined by histology, culture, and by the C-13-urea breath test. After collecting a 30 minute basal aspirate, GRP 40 pmol/kg/h was infused for 45 minutes, and after a 30 minute washout, pentagastrin 6 mu g/kg was injected intramuscularly.Results-Basal and stimulated acid output (PAO(GRP) and PAO(Pg)) were significantly higher in H pylori positive DU than in H pylori negative controls. Six months after H pylori eradication, basal and stimulated acid outputs were all significantly lower than before H pylori eradication.Conclusions-This study has shown that BAO, PAO(GRP), and PAO(Pg) are higher in H pylori positive DU than in H pylori negative controls. All decreased significantly six months after H pylori eradication, to fall within the range of controls. These results are compatible with a hypothesis that acid hypersecretion in duodenal ulcer disease is caused by H pylori infection.