BETA-ENDORPHIN AND NEUROTENSIN IN BRAIN-STEM AND CEREBROSPINAL-FLUID IN THE SUDDEN-INFANT-DEATH-SYNDROME
BETA-ENDORPHIN AND NEUROTENSIN IN BRAIN-STEM AND CEREBROSPINAL-FLUID IN THE SUDDEN-INFANT-DEATH-SYNDROME
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DOI：
10.1016/0197-0186(92)90131-a
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发表时间：
1992-01-01
影响因子：
4.2
通讯作者：
PROUST, B
中科院分区：
文献类型：
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作者：
COQUEREL, A;BUSER, M;PROUST, B
β-内啡肽（BE）和神经降压素（NT）是引起呼吸暂停的两种神经肽。对诊断为婴儿猝死综合征（SIDS）的婴儿，我们分别用IRMA和RIA法测定了脑干和CSF中的BE和NT。将BE和NT水平与相同年龄的婴儿和成人对照进行比较。SIDS的CSF BE水平显著高于两个对照组（86 +/- 14 vs 33 +/- 13和16 +/- 5 pmol/1）。6例SIDS患者取脑干正中、中间、外侧5个切片，测定NT和BE。我们发现BE在每个片段中的高水平（3-11 pmol/mg蛋白），而NT升高的值仅限于中脑区域（1.4-12 pmol/mg）、内侧脑桥（6 pmol/mg）和髓质的中间部分（包括橄榄：1.3-1.6 pmol/mg）。这些结果支持了NT和/或BE可能诱导或参与SIDS致命问题的假设。
Beta-endorphin (BE) and neurotensin (NT) are two neuropeptides which induce apneas. In infants who d&ed of Sudden Infant Death Syndrome (SIDS) we measured, in brainstem and CSF, BE and NT by IRMA and RIA respectively. BE and NT levels are compared to same aged infant and adult controls. CSF BE level was significantly higher in SIDS than in the two control groups (86 +/- 14 vs 33 +/- 13 and 16 +/- 5 pmol/1). In 6 SIDS victims NT and BE were assayed in 5 brainstem sections, each of them divided in median, intermediate and lateral parts. We found high levels of BE in every fragment (3-11 pmol/mg protein) while NT elevated values were restricted to the mesencephalic regions (1.4-12 pmol/mg), the medial pons (6 pmol/mg) and the intermediate parts of the medulla (including the olive: 1.3-1.6 pmol/mg). These results support the hypothesis that NT and/or BE could induce or participate to the fatal issue of SIDS.