Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates
Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates
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DOI：
10.7554/elife.15441
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发表时间：
2016-07-20
期刊：
影响因子：
7.7
通讯作者：
Brosch, Michael
中科院分区：
文献类型：
--
作者：
Huang, Ying;Matysiak, Artur;Brosch, Michael
工作记忆是对目标导向行为进行短时信息存储的认知能力。这种能力在哪里以及如何在大脑中实现是尚未解决的问题。我们表明，听觉皮层存储信息的持续变化的神经活动。我们通过让人类和猴子对相同的声音序列执行不同的任务，不同的工作记忆需求，将与工作记忆相关的活动与与其他心理过程相关的活动分开。工作记忆反映在听觉皮层单个神经元的尖峰活动和神经元群体的活动中，即在局部场电位和磁场中。我们的结果为信息临时存储招募了处理信息的相同大脑区域的想法提供了直接支持。由于在这两个物种中观察到类似的活动，因此可以在猴子中研究人类某些听觉工作记忆过程的细胞基础。
Working memory is the cognitive capacity of short-term storage of information for goal-directed behaviors. Where and how this capacity is implemented in the brain are unresolved questions. We show that auditory cortex stores information by persistent changes of neural activity. We separated activity related to working memory from activity related to other mental processes by having humans and monkeys perform different tasks with varying working memory demands on the same sound sequences. Working memory was reflected in the spiking activity of individual neurons in auditory cortex and in the activity of neuronal populations, that is, in local field potentials and magnetic fields. Our results provide direct support for the idea that temporary storage of information recruits the same brain areas that also process the information. Because similar activity was observed in the two species, the cellular bases of some auditory working memory processes in humans can be studied in monkeys.