Noninvasive and real‐time monitoring of the therapeutic response of tumors in vivo with an optimized hTERT promoter
Noninvasive and real‐time monitoring of the therapeutic response of tumors in vivo with an optimized hTERT promoter
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DOI：
10.1002/cncr.26476
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发表时间：
2012-04
期刊：
影响因子：
6.2
通讯作者：
Songtao Yu;Chuan Li;Mu-Han Lü;Guang-ping Liang;Ning Li;Xu-dong Tang;Yu-yun Wu;Chun-Meng Shi;Ling Chen;Chang-Zhu Li;Ya-Ling Cao;D. Fang;Shi-ming Yang
中科院分区：
文献类型：
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作者：
Songtao Yu;Chuan Li;Mu-Han Lü;Guang-ping Liang;Ning Li;Xu-dong Tang;Yu-yun Wu;Chun-Meng Shi;Ling Chen;Chang-Zhu Li;Ya-Ling Cao;D. Fang;Shi-ming Yang
端粒酶是公认的有效的抗癌靶点。人类端粒酶逆转录酶(HTERT)是端粒酶的限速成分，在大多数恶性肿瘤中都有表达，但在大多数正常体细胞中不表达。在这里，我们报告了一种实时和非侵入性的方法来监测肿瘤对基于慢病毒的hTERT条件自杀基因治疗的反应。
Telomerase is commonly recognized as an effective anticancer target. The human telomerase reverse transcriptase (hTERT), the rate‐limiting component of telomerase, is expressed in most malignant tumors, but it is not found in most normal somatic cells. Here, we report a real‐time and noninvasive method to monitor tumor response to a lentivirus‐based hTERT‐conditional suicidal gene therapy.