Astrocyte responses to neuronal activity
Astrocyte responses to neuronal activity
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DOI：
10.1002/glia.20029
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发表时间：
2004-08-15
期刊：
影响因子：
6.2
通讯作者：
Kettenmann, H
中科院分区：
文献类型：
--
作者：
Schipke, CG;Kettenmann, H
在过去的几年中，已经确定星形胶质细胞感知神经元活动并参与信号传递。在星形胶质细胞培养物和急性脑切片中，神经元刺激引发电生理和/或Ca 2+反应。甚至在一个给定的大脑区域内，已经描述了涉及不同受体系统的神经元到星形胶质细胞通信的不同途径。这些机制包括谷氨酸能和NO介导的信号传导。神经元到星形胶质细胞的信号传导可以局限于亚细胞区室，微区，或者它可以激活整个细胞。它甚至可以触发星形胶质细胞的多细胞反应，一种Ca 2+波。这种形式的星形胶质细胞长距离信号传播可以在纯星形胶质细胞培养物中独立发生，但也可以由神经元活动触发。星形胶质细胞还表现出自发的Ca 2+活性。急性脑切片中的神经元活动可以将这种活动组织成复杂的同步网络。神经元到星形胶质细胞信号传导的功能后果之一可能是使用星形胶质细胞作为介质的微循环的神经元控制。(C)2004 Wiley-Liss，Inc.
During the past few years, it has been established that astrocytes sense neuronal activity and are involved in signal transmission. Neuronal stimulation triggered electrophysiological and/or Ca2+ responses in astrocyte cultures and in acute brain slices. Present even within one given brain region, different pathways of neuron-to-astrocyte communication involving different receptor systems have been described. These mechanisms include glutamatergic and NO-mediated signaling. Neuron-to-astrocyte signaling can be confined to subcellular compartments, the microdomains, or it can activate the entire cell. It can even trigger a multicellular response in astrocytes, a Ca2+ wave. This form of astrocyte long-range signal propagation can occur independently, in pure astrocyte cultures, but it can also be triggered by neuronal activity. Astrocytes also exhibit spontaneous Ca2+ activity. Neuronal activity in acute brain slices can organize this activity into complex synchronous networks. One of the functional consequences of neuron-to-astrocyte signaling might be the neuronal control of microcirculation using astrocytes as a mediator. (C) 2004 Wiley-Liss, Inc.