A mad partner for Shugoshin in meiosis.

A mad partner for Shugoshin in meiosis.
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守护神减数分裂中的疯狂伙伴。

DOI:
10.1038/emboj.2011.217
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发表时间:
2011
期刊:
The EMBO journal
影响因子:
--
通讯作者:
Yu,Hongtao
Yu,Hongtao
中科院分区:
--
文献类型:
--
作者:
Yu,Hongtao

文献摘要

相似文献

已知着丝粒粘附蛋白保护剂Shugoshin(Sgo)和纺锤体检查点蛋白Mad2在不同的途径中起作用,以确保真核细胞分裂期间的准确染色体分离。EMBO杂志上的一项研究描述了脊椎动物Sgo和Mad2之间意想不到的物理相互作用,并暗示了它们在减数分裂中的潜在相互调节。
The centromeric cohesin protector Shugoshin (Sgo) and the spindle checkpoint protein Mad2 are known to act in distinct pathways for ensuring accurate chromosome segregation during eukaryotic cell division. A study in this issue ofThe EMBO Journaldescribes an unexpected physical interaction between vertebrate Sgo and Mad2, and hints to their potential mutual regulation in meiosis.