Prevalence and Predictors of Sleep-Disordered Breathing in Patients With Stable Chronic Heart Failure The SchlaHF Registry
Prevalence and Predictors of Sleep-Disordered Breathing in Patients With Stable Chronic Heart Failure The SchlaHF Registry
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DOI：
10.1016/j.jchf.2015.09.014
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发表时间：
2016-02-01
影响因子：
13
通讯作者：
Wegscheider, Karl
中科院分区：
文献类型：
--
作者：
Arzt, Michael;Woehrle, Holger;Wegscheider, Karl
目的探讨睡眠呼吸障碍(SDB)在稳定性慢性心力衰竭(HF)患者中的患病率及其预测因素。背景SDB在慢性心力衰竭(HF)患者中的重要性日益得到认可。方法多中心心力衰竭患者睡眠障碍呼吸(SchlaHF)登记提供慢性、稳定、有症状的HF患者的人口学和临床数据(纽约心脏协会功能分级分别为II级、70~80岁和80岁)。SDB的危险因素有体重指数(每5个单位；优势比[OR]：1.29；95%可信区间[CI]：1.22至1.36)、左心室排斥分数(每5%减少一次；OR：1.10；95%CI：1.06至1.14)、年龄(每10年相差60岁；OR：1.41；95%CI：1.34至1.49)、房颤(OR：1.19；95%CI：1.06~1.34)和男性(OR：1.90；95%CI：1.67~2.17)。结论SchlaHF登记数据显示，在接受现代医疗治疗的稳定慢性心力衰竭患者的代表性人群中，SDB的发病率很高。男性、年龄、体重指数、症状和左心功能不全的严重程度是SOB流行的临床预测因素。(《慢性、症状性、收缩性心力衰竭患者的睡眠障碍呼吸的流行率、临床特征和类型》，NCT01500759)(C)2016，美国心脏病学会基金会。
OBJECTIVES This prospective study investigated the prevalence of sleep-disordered breathing (SDB) and its predictors in patients with stable chronic heart failure (HF).BACKGROUND SDB is increasingly recognized as being important in patients with HF.METHODS The multicenter SchlaHF (Sleep-Disordered Breathing in Heart Failure) registry provides demographic and clinical data on chronic, stable, symptomatic patients with HF (New York Heart Association functional class >= II; left ventricular rejection fraction 70 to 80, and >80 years, respectively). Risk factors for SDB were body mass index (per 5 units; odds ratio [OR]: 1.29; 95% confidence interval [CI]: 1.22 to 1.36), left ventricular rejection fraction (per 5% decrement from 45%; OR: 1.10; 95% CI: 1.06 to 1.14), age (per 10-year difference to 60 years; OR: 1.41; 95% CI: 1.34 to 1.49), atrial fibrillation (OR: 1.19; 95% CI: 1.06 to 1.34), and male sex (OR: 1.90; 95% CI: 1.67 to 2.17).CONCLUSIONS SchlaHF registry data demonstrate a high prevalence of SDB in a representative population of stable patients with chronic HF receiving contemporary medical management. Male sex, age, body mass index, and the severity of both symptoms and left ventricular dysfunction were clinical predictors for prevalent SOB. (Prevalence, Clinical Characteristics and Type of Sleep-disordered Breathing in Patients With Chronic, Symptomatic, Systolic Heart Failure; NCT01500759) (C) 2016 by the American College of Cardiology Foundation.