SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs
SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs
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DOI：
10.1164/rccm.201506-1208pp
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发表时间：
2016-10-01
影响因子：
24.7
通讯作者：
Hoffman, Eric A.
中科院分区：
文献类型：
--
作者：
Sieren, Jered P.;Newell, John D., Jr.;Hoffman, Eric A.
多排计算机断层扫描（MDCT）越来越多地在慢性阻塞性肺疾病（COPD）、哮喘和其他肺部相关疾病人群的亚表型鉴定中发挥核心作用，允许定量改变的实质的数量和分布以及气道和血管解剖特征。在临床放射学环境中，将定量CT （QCT）嵌入到具有各种扫描仪制造和型号以及各种压力的多中心试验中已被证明具有挑战性，特别是在纵向研究的背景下。由美国国立卫生研究院（National Institutes of Health）赞助的SPIROMICS （COPD研究的亚群和中间结果测量）已经建立了一个QCT肺评估系统（QCT- las），其中包括用于肺总肺活量和残气量评估的扫描仪特异性成像方案。还包括每月扫描一个标准化的测试对象和基于web的工具，用于受试者注册、协议分配和数据传输，以及自动图像查询，以确保协议的遵守。SPIROMICS QCT-LAS已被越来越多的其他嵌入成像的多中心研究采用并做出了贡献。本文描述了SPIROMICS QCT-LAS的关键组成部分以及实施成功的证据。随着成像技术的不断发展，QCT- las所需的组件为未来的研究提供了框架，SPIROMICS产生的QCT结果和越来越多使用SPIROMICS QCT- las的其他研究将提供图像衍生的肺部指标的共享资源。
Multidetector row computed tomography (MDCT) is increasingly taking a central role in identifying subphenotypes within chronic obstructive pulmonary disease (COPD), asthma, and other lung related disease populations, allowing for the quantification of the amount and distribution of altered parenchyma along with the characterization of airway and vascular anatomy. The embedding of quantitative CT (QCT) into a multicenter trial with a variety of scanner makes and models along with the variety of pressures within a clinical radiology setting has proven challenging, especially in the context of a longitudinal study. SPIROMICS (Subpopulations and Intermediate Outcome Measures in COPD Study), sponsored by the National Institutes of Health, has established a QCT lung assessment system (QCT-LAS), which includes scanner-specific imaging protocols for lung assessment at total lung capacity and residual volume. Also included are monthly scanning of a standardized test object and web-based tools for subject registration, protocol assignment, and data transmission coupled with automated image interrogation to assure protocol adherence. The SPIROMICS QCT-LAS has been adopted and contributed to by a growing number of other multicenter studies in which imaging is embedded. The key components of the SPIROMICS QCT-LAS along with evidence of implementation success are described herein. While imaging technologies continue to evolve, the required components of a QCT-LAS provide the framework for future studies, and the QCT results emanating from SPIROMICS and the growing number of other studies using the SPIROMICS QCT-LAS will provide a shared resource of image-derived pulmonary metrics.