Tracking stem cells for cardiovascular applications in vivo: focus on imaging techniques.
Tracking stem cells for cardiovascular applications in vivo: focus on imaging techniques.
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DOI：
10.2217/iim.11.33
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发表时间：
2011-08-01
期刊：
影响因子：
--
通讯作者：
Kraitchman DL
中科院分区：
文献类型：
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作者：
Fu Y;Azene N;Xu Y;Kraitchman DL
尽管干细胞疗法迅速转化为临床实践，但使用胚胎干细胞、成体干细胞和祖细胞或诱导的多能干细胞治疗心血管疾病迄今尚未取得令人满意的结果。无创干细胞成像技术不仅可以更好地了解干细胞的治疗益处，而且可以更好地了解干细胞在体内的命运、迁移、存活和植入的基本机制。这些信息还有助于在心血管干细胞临床试验中适当选择干细胞类型(S)、传递途径和给药制度。多种成像手段，如MRI、PET、SPECT和CT，已经出现，提供了在体内定位、监测和跟踪干细胞的能力。这篇文章讨论了干细胞标记的方法，并重点介绍了最新的心脏干细胞成像技术，这些技术可能有助于临床医生、研究科学家或其他保健专业人员选择最好的细胞疗法来管理心血管疾病。
Despite rapid translation of stem cell therapy into clinical practice, the treatment of cardiovascular disease using embryonic stem cells, adult stem and progenitor cells or induced pluripotent stem cells has not yielded satisfactory results to date. Noninvasive stem cell imaging techniques could provide greater insight into not only the therapeutic benefit, but also the fundamental mechanisms underlying stem cell fate, migration, survival and engraftment in vivo. This information could also assist in the appropriate choice of stem cell type(s), delivery routes and dosing regimes in clinical cardiovascular stem cell trials. Multiple imaging modalities, such as MRI, PET, SPECT and CT, have emerged, offering the ability to localize, monitor and track stem cells in vivo. This article discusses stem cell labeling approaches and highlights the latest cardiac stem cell imaging techniques that may help clinicians, research scientists or other healthcare professionals select the best cellular therapeutics for cardiovascular disease management.