Manganese-enhanced magnetic resonance imaging in dilated cardiomyopathy and hypertrophic cardiomyopathy
Manganese-enhanced magnetic resonance imaging in dilated cardiomyopathy and hypertrophic cardiomyopathy
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DOI：
10.1093/ehjci/jeaa273
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发表时间：
2021-12-01
影响因子：
6.2
通讯作者：
Semple, S., I
中科院分区：
文献类型：
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作者：
Spath, N. B.;Singh, T.;Semple, S., I
目的应用磁共振成像技术定量检测非缺血性心肌病患者心肌钙离子转运的改变。方法对10例扩张型心肌病和17例肥厚型心肌病患者同时行Gd和锰对比增强磁共振成像，并与20例健康志愿者进行比较。差异锰摄取(KI)用两室Patlak模型评估。与健康志愿者相比，扩张型心肌病患者锰增强磁共振成像的T1缩短较低[平均缩短257+/-45(21%)对288+/-34(26%)ms，P<；0.001]，40分钟时T1较高(948+/-57对834+/-28 ms，P<0.05)。
Aims The aim of this study is to quantify altered myocardial calcium handling in non-ischaemic cardiomyopathy using magnetic resonance imaging.Methods Patients with dilated cardiomyopathy (n = 10) or hypertrophic cardiomyopathy (n = 17) underwent both gadolinium and results and manganese contrast-enhanced magnetic resonance imaging and were compared with healthy volunteers (n = 20). Differential manganese uptake (Ki) was assessed using a two-compartment Patlak model. Compared with healthy volunteers, reduction in T1 with manganese-enhanced magnetic resonance imaging was lower in patients with dilated cardiomyopathy [mean reduction 257 +/- 45 (21%) vs. 288 +/- 34 (26%) ms, P < 0.001], with higher T1 at 40 min (948 +/- 57 vs. 834 +/- 28 ms, P