Ichthyosis, Inherited, Skin, Mouse (ic/ic)
Ichthyosis, Inherited, Skin, Mouse (ic/ic)
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鱼鳞病，遗传性，皮肤，小鼠 (ic/ic)
DOI：
10.1007/978-3-642-83749-4_37
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
K. Holbrook
中科院分区：
文献类型：
--
作者：
K. Holbrook
纯合型鱼鳞病（ic/ic）动物与杂合型同窝出生的同窝出生ic/ic表型的表达差异很大，即使在受影响的同窝仔中也是如此（Carter和菲利普斯1950;詹森和埃斯特里1977）。受严重影响的动物有厚厚的、融合的、坚硬的皮肤板，这些板会破裂并逐渐脱落。毛发通常数量减少，动物几乎秃顶。轻度受累动物的毛囊口周围有小鳞片，局限于足、尾和耳（詹森和埃斯特里，1971）（图287）。
Homozygous ichthyotic (ic/ic) animals are easily distinguished from heterozygous littermates by their smaller size, short, sparse coat, scaliness of “bare” skin (paws, ears, tail), short vibrissae, and accumulation of scale superimposed upon segmental rings of the tail (Fig. 286). Expression of the ic/ic phenotype varies considerably, even among affected littermates (Carter and Phillips 1950; Jensen and Esterly 1977). Severely affected animals have thick, confluent, rigid, cutaneous plates that crack and are gradually shed. The hair is usually diminished in quantity, and animals can be nearly bald. Mildly affected animals have small scales surrounding the orifices of hair follicles confined to the feet, tail, and ears (Jensen and Esterly 1971) (Fig. 287).