Progress in studies on the antimutagenicity and anticarcinogenicity of green tea epicatechins.
Progress in studies on the antimutagenicity and anticarcinogenicity of green tea epicatechins.
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绿茶表儿茶素抗突变和抗癌作用研究进展
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
X. Hu
中科院分区：
文献类型：
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作者：
S. Cheng;L. Ding;Y. Zhen;P. Lin;Y. Zhu;Y. Chen;X. Hu
从绿色茶中提取了一种抗氧化组分，并鉴定了该组分中的主要成分为表儿茶素。实验结果表明，绿色茶表儿茶素化合物（GTEC）对细菌和哺乳动物细胞的致突变性和/或不同致癌物引起的染色体损伤均有抑制作用。GTEC在体外可抑制BP、X射线或MCA/TPA诱导的BALB/3 T3细胞转化。在体内，绿色茶提取物可降低肌氨酸和亚硝酸钠诱导的小鼠前胃和食管癌的发生率。GTEC抑制二乙基亚硝胺（DEN）或DEN/苯巴比妥处理的大鼠肝脏中γ-谷氨酰转肽酶阳性病灶的发展。我们的研究表明，GTBC的抗突变和抗癌机制与以下有关：增加谷胱甘肽-S-转移酶活性;抑制TPA诱导的水肿，增生和ODC活性;清除自由基;阻断肿瘤促进剂诱导的细胞间通讯抑制;和增强细胞介导的免疫。GTEC可用于预防某些类型的癌症和多种氧化相关疾病。
An antioxidative fraction was extracted from green tea and the major compounds in the fraction identified as epicatechins. Experimental results showed that green tea epicatechin compounds (GTEC) inhibited the mutagenicity and/or chromosomal damage caused by different carcinogens in both bacterial and mammalian cells. In vitro, GTEC inhibited transformation of BALB/3T3 cells induced by BP, X-rays, or MCA/TPA. In vivo, green tea extract decreased the incidence of carcinoma in the forestomach and esophagus of mice induced by sarcosine and NaNO2. GTEC inhibited the development of gamma-glutamyl transpeptidase-positive foci in the livers of rats treated with diethyl nitrosamine (DEN) or DEN/phenobarbital. Our investigations indicate that the antimutagenic and anticarcinogenic mechanisms of GTBC are related to the following: increased glutathione-S-transferase activity; inhibition of edema, hyperplasia, and ODC activity induced by TPA; free radical scavenging; blocked tumor promoter-induced inhibition of intercellular communication; and enhanced cell-mediated immunity. GTEC might be useful in the prevention of some kinds of cancer and a variety of oxidation-related diseases.