Antiviral activity of itraconazole against type I feline coronavirus infection
Antiviral activity of itraconazole against type I feline coronavirus infection
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DOI：
10.1186/s13567-019-0625-3
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发表时间：
2019-01-18
影响因子：
4.4
通讯作者：
Hohdatsu, Tsutomu
中科院分区：
文献类型：
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作者：
Takano, Tomomi;Akiyama, Misuzu;Hohdatsu, Tsutomu
猫冠状病毒（FCoV）是家猫和野猫严重全身性疾病（猫传染性腹膜炎：FIP）的病原体。 FCoV 被分为血清型 I 和 II。 I 型 FCoV 是全球主要血清型（约 70-90%）。因此，有必要针对I型FCoV感染提供抗病毒药物。在这项研究中，我们证明了伊曲康唑 (ICZ) 可抑制 I 型 FCoV 感染，该药物实际上用于治疗猫的真菌感染。 ICZ 还在病毒感染后的细胞中表现出抗病毒作用，这表明 ICZ 有可能用作治疗剂。
Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70-90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.