Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level.
Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level.
复制标题
尼古丁代谢物比预测吸烟地形和致癌生物标志物水平。
DOI：
10.1158/1055-9965.epi-10-0674
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Lerman CE
中科院分区：
文献类型：
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作者：
Strasser AA;Benowitz NL;Pinto AG;Tang KZ;Hecht SS;Carmella SG;Tyndale RF;Lerman CE
吸烟行为的变异性部分归因于尼古丁清除率的可遗传个体差异。这可以通过代谢物可替宁（COT）和3 '-羟基可替宁（3 HC）的比值（称为尼古丁代谢比，NMR）进行评估。我们假设，更快的NMR将与更大的香烟抽吸量和更高水平的总NNAL（一种致癌物生物标志物）相关。当前吸烟者（n=109）通过吸烟地形图设备吸烟他们的首选品牌香烟之一，并提供标本进行NMR和总NNAL测定。基于NMR的尼古丁代谢较快者（第三和第四四个四分位数与第一个四分位数）表现出显著更大的总抽吸量和总NNAL;总抽吸量与每日卷烟消费量的相互作用是总NNAL水平的显著预测因子。尼古丁清除的遗传生物标志物可预测总吸烟量和总NNAL。如果得到验证，核磁共振可能有助于流行病学研究和潜在的临床实践中的吸烟风险评估。
Variability in smoking behavior is partly attributable to heritable individual differences in nicotine clearance rates. This can be assessed as the ratio of the metabolites cotinine (COT) and 3'-hydroxycotinine (3HC) (referred to as the nicotine metabolism ratio, NMR). We hypothesized that faster NMR would be associated with greater cigarette puff volume and higher levels of total NNAL, a carcinogen biomarker. Current smokers (n=109) smoked one of their preferred brand cigarettes through a smoking topography device and provided specimens for NMR and total NNAL assays. Faster nicotine metabolizers (third and fourth quartiles versus first quartile) based on the NMR exhibited significantly greater total puff volume and total NNAL; the total puff volume by daily cigarette consumption interaction was a significant predictor of total NNAL level. A heritable biomarker of nicotine clearance predicts total cigarette puff volume and total NNAL. If validated, the NMR could contribute to smoking risk assessment in epidemiological studies and potentially in clinical practice.