Improving Sequence Alignments For Intrinsically Disordered Proteins
Improving Sequence Alignments For Intrinsically Disordered Proteins
复制标题
改善本质无序蛋白质的序列比对
DOI：
10.1142/9789812799623_0055
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发表时间：
2001
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通讯作者：
A. Dunker
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作者：
P. Radivojac;Z. Obradovic;C. Brown;A. Dunker
Here we analyze sequence alignments for intrinsically disordered proteins. For 55 disordered protein families we measure the performance of different scoring matrices and propose one adjusted to disordered regions. An iterative algorithm of realigning sequences and recalculating matrices is designed and tested. For each matrix we also test a wide range of gap penalties. Results show an improvement in the ability to detect and discriminate related disordered proteins whose average sequence identity with the other family members is below 50%.
R.G.Duggleby：“酶学方法”
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