[Autoantigen BiP and autoimmune diseases].
[Autoantigen BiP and autoimmune diseases].
复制标题
[自身抗原BiP与自身免疫性疾病]。
DOI：
10.2177/jsci.35.46
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kazuhiko Yamamoto
中科院分区：
文献类型：
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作者：
H. Shoda;K. Fujio;Kazuhiko Yamamoto
免疫球蛋白结合蛋白（BiP）是热休克蛋白70家族的成员，也被认为是类风湿关节炎（RA）患者的自身抗原。抗BiP抗体在RA患者中的检出率高达60%，近年来的研究表明，在系统性红斑狼疮患者中也可检测到抗BiP抗体。值得注意的是，抗瓜氨酸化BiP抗体是抗瓜氨酸化蛋白/肽抗体（ACPA）的另一个成员。由于ACPAs被认为与RA发病机制密切相关，因此对瓜氨酸化BiP的免疫应答可能在RA中起重要作用。事实上，瓜氨酸化BiP的免疫加重了小鼠的炎性关节炎。此外，在人RA和小鼠模型中报道了T细胞对BiP的应答。在小鼠模型中，天然BiP给药诱导产生IL-4和IL-10的CD 4（+）T细胞并调节炎性关节炎。以这种方式，对BiP的免疫应答是多种多样的，并且对BiP的促炎和调节应答之间的平衡失调可能导致自身免疫应答和疾病。
Immunoglobulin Binding Protein (BiP) is a member of heat shock protein 70 famaily, and is also known as an autoantigen in rheumatoid arthritis (RA) patients. Serum anti-BiP antibody is detected up to 60% of RA patients, and recent reports demonstrated that serum anti-BiP antibody is also detected in systemic lupus erythematosus patients. Notably, anti-citrullinated BiP antibody is revealed as another member of anti-citrullinated protein/peptide antibodies (ACPAs). Since ACPAs are supposed to be closely associated with RA pathogenesis, immune responses to citrullinated BiP could play an important role in RA. Indeed, immunization of citrullinated BiP exacerbated inflammatory arthritis in mice. Moreover, T cell responses to BiP were reported in human RA and mice models. In mice models, native BiP administration induced IL-4 and IL-10 producing CD4(+) T cells and regulated inflammatory arthritis. In this way, immune responses to BiP are various, and dysregulation of the balances between pro-inflammatory and regulatory responses to BiP could lead to the autoimmune responses and diseases.
影响因子：
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作者：
Lundberg, Karin;Kinloch, Andrew;Venables, Patrick J.
通讯作者：
Venables, Patrick J.