Acute exercise enhancement of pneumococcal vaccination response: A randomised controlled trial of weaker and stronger immune response
Acute exercise enhancement of pneumococcal vaccination response: A randomised controlled trial of weaker and stronger immune response
复制标题
DOI：
10.1016/j.vaccine.2012.08.022
复制
发表时间：
2012-10-05
期刊：
影响因子：
5.5
通讯作者：
Mills, Paul J.
中科院分区：
文献类型：
--
作者：
Edwards, Kate M.;Pung, Meredith A.;Mills, Paul J.
接种疫苗时的急性运动可以增强随后的免疫反应。然而，这种效应的潜在好处将是其在促进不良反应方面的功效，从而保护高危人群。目前的研究测试了运动对全剂量或半剂量肺炎球菌（Pn）疫苗接种反应的影响，以引起更强和更弱的反应。受试者为133名健康的年轻成年人，随机分为四组：运动组或对照组，接受全剂量或半剂量的Pn疫苗接种。接种前，运动组完成15 min的手臂和肩部运动任务，对照组安静休息。在基线和1个月时评价了11株Pn菌株的抗体水平。在所有参与者中，运动组的抗体水平显着高于对照组。当比较剂量时，发现那些锻炼的人比那些在半剂量组中休息的人有更大的反应，但在全剂量组中，反应是相似的。这些数据表明了运动作为疫苗佐剂的有效性，特别是在较弱的反应中。因此，考虑到无成本行为干预对增强疫苗接种反应的潜在公共卫生益处，应继续在高危人群中进行检测。(C)2012爱思唯尔有限公司保留所有权利。
Acute exercise at the time of vaccination can enhance subsequent immune responses. However, the potential benefit of this effect will be its efficacy in boosting poor responses, and thus protection in at-risk populations. The current study tested the effect of exercise on the response to either a full- or half-dose Pneumococcal (Pn) vaccination to elicit stronger and weaker responses. Subjects were 133 young healthy adults, randomised to one of four groups: exercise or control task, receiving a full- or half-dose Pn vaccination. Prior to vaccination, exercise groups completed a 15 min arm and shoulder exercise task, control groups rested quietly. Antibody levels to 11 Pn strains were evaluated at baseline and 1-month. Across all participants, exercise groups showed significantly greater increase in antibody levels than control groups. When doses were compared, it emerged that those who exercised had significantly larger responses than those who rested in the half-dose group, but in the full-dose groups responses were similar. This data indicates the effectiveness of exercise as a vaccine adjuvant, particularly in weaker responses. Thus, given the potential public health benefits of no-cost behavioural intervention to enhance response to vaccination, testing in at-risk populations should be pursued. (C) 2012 Elsevier Ltd. All rights reserved.