Living Organ Donor Perspectives and Sources of Hesitancy about COVID-19 Vaccines.
Living Organ Donor Perspectives and Sources of Hesitancy about COVID-19 Vaccines.
复制标题
DOI：
10.34067/kid.0002112021
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Lentine KL
中科院分区：
文献类型：
--
作者：
Harhay MN;Klassen AC;Zaidi H;Mittelman M;Bertha R;Mannon RB;Lentine KL
在COVID-19大流行期间，由于对捐赠者和移植候选人安全的担忧，美国的活体器官捐赠大幅减少。COVID-19疫苗可能会增加对大流行期间活体器官捐赠安全性的信心。我们评估了美国活体器官捐赠者和潜在捐赠者对COVID-19疫苗的信息偏好和观点。我们在2020年12月28日至2021年2月23日期间在社交媒体平台上对器官捐赠者和潜在捐赠者进行了一项全国性调查研究。调查项目包括多项选择、视觉模拟量表和开放式回答。我们使用多变量logistic回归分析了信息偏好、COVID-19感染史、流感疫苗接种史和COVID-19疫苗接受度之间的关系，并对开放式回答进行了主题分析。在来自美国47个州和哥伦比亚特区的342名受访者中，35%的人年龄在51-70岁之间，90%为非西班牙裔白色人，87%为女性; 82%为活体捐赠者（94%为肾脏），18%为评估捐赠者（75%为肾脏）。大多数人计划或已经接种COVID-19疫苗（76%），而11%的人不计划接种疫苗，12%的人不确定。根据人口统计学和献血者特征进行调整后，每年接种流感疫苗的受访者对COVID-19疫苗的接受程度高于未接种疫苗的受访者（调整后的比值比[aOR] 5.06，95%置信区间[CI] 2.68-9.53）。与优先考虑医疗信息来源的受访者相比（例如，私人医生和移植提供者），优先关注新闻和社交媒体的人对COVID-19疫苗的接受程度较低（aOR 0.34，95%CI 0.15-0.73）。接种疫苗的个人效益低和长期安全性的不确定性是那些拒绝接种COVID-19疫苗的人的共同主题。捐赠者的信息来源偏好与接受COVID-19疫苗的可能性密切相关。对于不确定COVID-19疫苗的器官捐献者，疫苗指导可以包括关于健康人接种疫苗的安全性和益处的信息。
Living organ donation declined substantially in the United States during the COVID-19 pandemic due to concerns about donor and transplant candidate safety. COVID-19 vaccines might increase confidence in the safety of living organ donation during the pandemic. We assessed informational preferences and perspectives about COVID-19 vaccines among US living organ donors and prospective donors. We conducted a national survey study of organ donors and prospective donors on social media platforms between 12/28/2020–2/23/2021. Survey items included multiple choice, visual analog scale, and open-ended responses. We examined associations between information preferences, history of COVID-19 infection, influenza vaccination history and COVID-19 vaccine acceptance using multivariable logistic regression and performed a thematic analysis of open-ended responses. Among 342 respondents from 47 US states and the District of Columbia, 35% were between 51–70 years old, 90% were non-Hispanic white, 87% were women; 82% were living donors (94% kidney) and 18% in evaluation to donate (75% kidney). The majority planned to or had received COVID-19 vaccination (76%), whereas 11% did not plan to be receive a vaccine, and 12% were unsure. Adjusting for demographics and donor characteristics, respondents who receive yearly influenza vaccinations had higher COVID-19 vaccine acceptance than those who do not (adjusted Odds Ratio [aOR] 5.06, 95% Confidence Interval [CI] 2.68–9.53). Compared to respondents who prioritized medical information sources (e.g., personal physicians and transplant providers), those who prioritized news and social media had lower COVID-19 vaccine acceptance (aOR 0.34, 95% CI 0.15–0.73). Low perceived personal benefit from vaccination and uncertainty about long-term safety were common themes among those declining COVID-19 vaccines. Donor informational source preferences were strongly associated with the likelihood of accepting a COVID-19 vaccine. Vaccine guidance for organ donors who are unsure about COVID-19 vaccines could incorporate messaging about safety and benefits of vaccination for healthy people.