Overshadowing effects in the stimulus control of morphine analgesic tolerance.
Overshadowing effects in the stimulus control of morphine analgesic tolerance.
复制标题
吗啡镇痛耐受的刺激控制的掩盖作用。
DOI：
10.1037//0735-7044.97.4.658
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发表时间：
1983
影响因子：
1.9
通讯作者：
Riccio,DC
中科院分区：
文献类型：
--
作者：
Walter,TA;Riccio,DC
试图复制以前的经典条件反射的吗啡镇痛耐受的演示，并确定是否刺激遮蔽效应可能解释以前的矛盾的结果。在实验I中，8组雄性Sprague-Dawley大鼠接受了一系列10次吗啡（5 mg/kg）和/或盐水注射，不同之处仅在于复合视听CS和注射物质之间的偶然性。当在化合物CS存在下测试对吗啡的镇痛反应时，只有在采集序列期间CS和吗啡注射配对的那些组证明耐受性。在实验II中，在化合物CS的1种组分存在下测试耐受性Ss。当在化合物中使用响亮的音调（85分贝）时，较弱的视觉刺激单独引起较低的镇痛耐受性。这种差异刺激控制的镇痛反应表明，遮蔽可能有助于失败复制条件吗啡耐受。内部吗啡产生的刺激可能会掩盖外部线索。(18参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Attempted to replicate previous demonstrations of classical conditioning of morphine analgesic tolerance and to determine whether stimulus overshadowing effects might explain previous conflicting findings. In Exp I, 8 groups of male Sprague-Dawley rats received a series of 10 morphine (5 mg/kg) and/or saline injections, differing only with respect to the contingency between a compound visual-auditory CS and the substance injected. When tested for analgesic responding to morphine in the presence of the compound CS, only those groups for which the CS and morphine injections were paired during the acquisition sequence evidenced tolerance. In Exp II, tolerant Ss were tested in the presence of 1 component of the compound CS. When a loud tone (85 db) was used in the compound, less analgesic tolerance was elicited later by the weaker visual stimulus alone. This differential stimulus control of the analgesic response suggests that overshadowing may contribute to failures to replicate conditioned morphine tolerance. It is possible that internal morphine-produced stimuli may overshadow external cues.(18 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)