Is there a blood-brain barrier at the optic nerve head?
Is there a blood-brain barrier at the optic nerve head?
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DOI：
10.1001/archopht.1975.01010020703008
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发表时间：
1975-09
影响因子：
--
通讯作者：
Mark O. M. Tso;C. Shih;Ian W. McLean
中科院分区：
文献类型：
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作者：
Mark O. M. Tso;C. Shih;Ian W. McLean
视网膜和视神经已被证明具有血脑屏障，阻止蛋白质和某些染料从血管被动进入细胞外空间。我们的观察表明，在正常视盘中存在例外。用辣根过氧化物酶作为电子显微镜示踪剂，以正常恒河猴为实验动物，证明在视神经头的某些区域，血液中的辣根过氧化物酶从邻近的脉络组织通过Elschnig边缘组织到达视神经轴突。视盘边缘的神经胶质细胞之间的一系列细胞连接形成的屏障阻止示踪剂从视盘扩散到视网膜下空间。
The retina and optic nerve have been demonstrated to possess a blood-brain barrier that prevents the passive passage of protein and certain dyes from the blood vessels into the extracellular space. Our observations suggest that an exception is present at the normal optic disc. Using horseradish peroxidase as a tracer for electron microscopy and the normal rhesus monkey as the experimental animal, we have demonstrated that in certain regions of the optic nerve head, horseradish peroxidase from the blood stream reaches the axons of the optic nerve through the border tissue of Elschnig from the adjacent choridal tissues. A barrier formed by a series of cell junctions between glial cells at the edge of the optic disc prevented spread of the tracer from the optic disc into the subretinal space.