CYTOPLASMIC MICROTUBULAR DYNAMICS AND CHROMATIN ORGANIZATION DURING MAMMALIAN OOGENESIS AND OOCYTE MATURATION
CYTOPLASMIC MICROTUBULAR DYNAMICS AND CHROMATIN ORGANIZATION DURING MAMMALIAN OOGENESIS AND OOCYTE MATURATION
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DOI：
10.1016/0165-1110(92)90032-5
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发表时间：
1992-12-01
期刊：
影响因子：
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通讯作者：
ALBERTINI, DF
中科院分区：
文献类型：
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作者：
ALBERTINI, DF
在哺乳动物卵子发生和成熟过程中，卵母细胞染色体和微管分布发生了一系列按时间顺序的协调变化。由于微管蛋白池的组装能力和中心体的成核能力的改变，减数分裂纺锤体和细胞质微管的及时转变强调了减数分裂I和II的进行性阶段中的关键核事件。讨论了减数分裂期间这些过渡状态的调节，包括对滤泡微环境中卵母细胞的激素影响，以及环境扰动可能导致减数分裂期间染色体分配缺陷的可能方式。
A chronological series of coordinated alterations in oocyte chromosome and microtubule disposition occur during oogenesis and oocyte maturation in the mammal. Timely transitions in meiotic spindle and cytoplasmic microtubules, due to modifications in both the assembly competence of the tubulin pool and nucleation capacity of centrosomes, underscore key nuclear events during the progressive stages of meiosis I and II. The regulation of these transitional states during meiosis is discussed with respect to hormonal influences imparted to the oocyte within the follicular microenvironment, and the possible ways in which environmental perturbations may result in defective chromosomal partitioning during meiosis.