Enhancement of contrast echocardiography by image variability analysis.
Enhancement of contrast echocardiography by image variability analysis.
复制标题
通过图像变异性分析增强超声心动图对比。
DOI：
10.1109/42.963815
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发表时间：
2001
影响因子：
10.6
通讯作者：
Nevo,E
中科院分区：
文献类型：
--
作者：
Fetics,BJ;Wong,EY;Murabayashi,T;Nelson,GS;Cohen,MM;Rochitte,CE;Weiss,JL;Kass,DA;Nevo,E
尽管超声心动图最近取得了进展，但由于图像质量差和血液-心肌边界不清晰，许多研究仍然不够理想。作者开发了一种新颖的图像处理技术——心脏变异成像（CVI），该技术基于超声微泡造影剂进入左心室期间像素强度值的变化，旨在增强心内膜边界描绘和图像质量。对模拟数据进行CVI分析，以测试和验证图像增强的机制。然后将 CVI 分析应用于两项不同临床研究中获得的超声心动图图像，并由专家评审员对静态图像进行解读。在第一项研究 (N=15) 中，使用造影剂 EchoGen，例如，与造影前 (3.28) 和造影图像 (3.36) 相比，CVI (4.93) 显着增加了舒张末期图像中可观察到的壁段数量，与 CVI 相比，P<0.001。在第二项研究 (N=8) 中，使用造影剂 Optison，与造影前 (63.4) 和造影图像 (49.0) 相比，使用 CVI (22.3 ml) 手动追踪的舒张末期容积的观察者间变异性显着降低，与 CVI 相比，P<0.01。总之，CVI 可以显着增强心内膜边界描绘并改善超声心动图图像质量和图像解释。
Although there have been recent advances in echocardiography, many studies remain suboptimal due to poor image quality and unclear blood-myocardium border. The authors developed a novel image processing technique, cardiac variability imaging (CVI), based on the variance of pixel intensity values during passage of ultrasound microbubble contrast into the left ventricle chamber, with the aim of enhancing endocardial border delineation and image quality. CVI analysis was performed on simulated data to test and verify the mechanism of image enhancement. Then CVI analysis was applied to echocardiographic images obtained in two different clinical studies, and still images were interpreted by expert reviewers. In the first study (N=15), using contrast agent EchoGen, the number of observable wall segments in end-diastolic images, for example, was significantly increased by CVI (4.93) as compared to precontrast (3.28) and contrast images (3.36), P<0.001 for both comparisons to CVI. In the second study (N=8), using contrast agent Optison, interobserver variability of manually traced end-diastolic volumes was significantly decreased using CVI (22.3 ml) as compared to precontrast (63.4) and contrast images (49.0), P<0.01 for both comparisons to CVI. In conclusion, CVI can substantially enhance endocardial border delineation and improve echocardiographic image quality and image interpretation.